Protein Info for IAI47_10205 in Pantoea sp. MT58

Annotation: pyrroloquinoline quinone biosynthesis protein PqqE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 380 TIGR02109: coenzyme PQQ biosynthesis enzyme PqqE" amino acids 7 to 367 (361 residues), 624.2 bits, see alignment E=6.3e-192 PF04055: Radical_SAM" amino acids 18 to 174 (157 residues), 102 bits, see alignment E=6.5e-33 PF13353: Fer4_12" amino acids 21 to 103 (83 residues), 22.6 bits, see alignment E=1.8e-08 PF13186: SPASM" amino acids 245 to 310 (66 residues), 29.3 bits, see alignment E=1.3e-10

Best Hits

Swiss-Prot: 89% identical to PQQE_KLEP3: PqqA peptide cyclase (pqqE) from Klebsiella pneumoniae (strain 342)

KEGG orthology group: K06139, pyrroloquinoline quinone biosynthesis protein E (inferred from 97% identity to pva:Pvag_1286)

MetaCyc: 89% identical to glutamate Cgamma--tyrosine C3 ligase (Klebsiella pneumoniae)
RXN-11176 [EC: 1.21.98.4]

Predicted SEED Role

"Coenzyme PQQ synthesis protein E" in subsystem Coenzyme PQQ synthesis or Pyrroloquinoline Quinone biosynthesis

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.21.98.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (380 amino acids)

>IAI47_10205 pyrroloquinoline quinone biosynthesis protein PqqE (Pantoea sp. MT58)
MTPHKPGVNPPLWLLAELTYRCPLQCPYCSNPLDFAQQEKELTTEQWIEVFRQARAMGSV
QLGFSGGEPLVRKDLPELIKAARDLGFYTNLITSGIGLTEKKLDAFSEAGLDHIQISFQA
SDETLNAALAGSKKAFQQKLEMAKAVKAHGYPMVLNFVLHRHNIDQIDKIIDLCIELEAD
DVELATCQFYGWAQLNREGLLPTREQIARAEAVVKTYRERMSTTGNLTNLLFVTPDYYEE
RPKPCMGGWGAIFLSVTPEGTALPCHSARQLPVEFPSVLTQSLDDIWYNSFGFNRYRGFD
WMPEPCRSCDEKEKDFGGCRCQAFMLTGNADNTDPVCSKSPHHGKILEARREADCSDIKI
GQLQFRNRSNSQLIYKTRNL