Protein Info for IAI47_09990 in Pantoea sp. MT58

Annotation: bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00294: PfkB
  • amino acids 1 to 283 (283 residues), 164.9 bits, E=2.9e-52
• PF08543: Phos_pyr_kin
  • amino acids 177 to 282 (106 residues), 35.8 bits, E=5.8e-13

Best Hits

KEGG orthology group: K00852, ribokinase [EC: 2.7.1.15] (inferred from 72% identity to pam:PANA_1877)

Predicted SEED Role

"Ribokinase (EC 2.7.1.15)" in subsystem D-ribose utilization or Deoxyribose and Deoxynucleoside Catabolism (EC 2.7.1.15)

MetaCyc Pathways

• 2-deoxy-D-ribose degradation I (3/3 steps found)
• ribose phosphorylation (2/2 steps found)

KEGG Metabolic Maps

• Pentose phosphate pathway

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.15

Use Curated BLAST to search for 2.7.1.15

Protein Sequence (286 amino acids)

>IAI47_09990 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase (Pantoea sp. MT58)
MSKIAVTGSLHYDIMLDAHHRPEKGETVMGSACHYKFGGKGGNQAVAAARAGAAVRFAGS
VGRDQQGKFLLDHLQQAGVDCTQVSVTDALPSGMSVAITDAEGDYGAVVVSNANQQIPLE
TFAQPGFWQDVSLLVLQNEVPEAVNLCAAQAARQRGITVCVNAAPARTLSAAFEGCIDLL
VVNAIEARDMCGINVQDLTSARAAAASLAGRFARVVVTAGEHGVAYSEAGETHTLAAQKV
TLVSTHGAGDCFVGVLCQRLSLGATLGEAVSDANRAAAEHVSRQPH