Protein Info for IAI47_09180 in Pantoea sp. MT58
Annotation: anthranilate phosphoribosyltransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 81% identical to TRPD_ERWT9: Anthranilate phosphoribosyltransferase (trpD) from Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
KEGG orthology group: K13497, anthranilate synthase/phosphoribosyltransferase [EC: 2.4.2.18 4.1.3.27] (inferred from 98% identity to pva:Pvag_1506)Predicted SEED Role
"Anthranilate phosphoribosyltransferase (EC 2.4.2.18)" in subsystem Auxin biosynthesis or Tryptophan synthesis (EC 2.4.2.18)
MetaCyc Pathways
- superpathway of aromatic amino acid biosynthesis (18/18 steps found)
- superpathway of L-tryptophan biosynthesis (13/13 steps found)
- superpathway of chorismate metabolism (44/59 steps found)
- L-tryptophan biosynthesis (6/6 steps found)
- L-glutamate and L-glutamine biosynthesis (6/7 steps found)
- ammonia assimilation cycle III (3/3 steps found)
- L-glutamate biosynthesis I (2/2 steps found)
- L-glutamine degradation I (1/1 steps found)
- L-asparagine biosynthesis III (tRNA-dependent) (3/4 steps found)
- glutaminyl-tRNAgln biosynthesis via transamidation (3/4 steps found)
- L-citrulline biosynthesis (5/8 steps found)
- 4-hydroxy-2(1H)-quinolone biosynthesis (2/5 steps found)
- superpathway of L-citrulline metabolism (7/12 steps found)
- acridone alkaloid biosynthesis (1/4 steps found)
- superpathway of quinolone and alkylquinolone biosynthesis (2/10 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Phenylalanine, tyrosine and tryptophan biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 2.4.2.18, 4.1.3.27
Use Curated BLAST to search for 2.4.2.18 or 4.1.3.27
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (332 amino acids)
>IAI47_09180 anthranilate phosphoribosyltransferase (Pantoea sp. MT58) MQQTLEKLYQAQTLNQAESHALFSAIITGQLEPTQLAAALVAMKVRGETPEEIAGAATAL LEDAKPFPRPDYAFADIVGTGGDGSNSINISTASAFAAATCGLKVAKHGNRSVSSKSGSS DLLAAFGINLDMPADRARQALDDLNVCFLFAPQYHTGFRHAMPVRQQLKTRTLFNVLGPL INPARPPLAVIGVYSPDLVMPIAQTLKVLGYQRAAVVHGGGMDEVALHDVTHVAELREGE ITRYQLSPEDFGFGFHPKEALAGGTPEENRDILTALLQGNGQQAHEEAVAVNVAMLLKVF GQEDLRENAQQALNAIRSGQAYERVVALAARG