Protein Info for IAI47_08650 in Pantoea sp. MT58
Annotation: betaine-aldehyde dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 84% identical to BETB_ECOHS: NAD/NADP-dependent betaine aldehyde dehydrogenase (betB) from Escherichia coli O9:H4 (strain HS)
KEGG orthology group: K00130, betaine-aldehyde dehydrogenase [EC: 1.2.1.8] (inferred from 98% identity to pva:Pvag_1615)MetaCyc: 83% identical to betaine aldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Betaine-aldehyde dehydrogenase. [EC: 1.2.1.8]
Predicted SEED Role
"Betaine aldehyde dehydrogenase (EC 1.2.1.8)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.2.1.8)
MetaCyc Pathways
- choline degradation I (2/2 steps found)
- glycine betaine biosynthesis I (Gram-negative bacteria) (2/2 steps found)
- glycine betaine biosynthesis II (Gram-positive bacteria) (2/2 steps found)
- choline-O-sulfate degradation (2/3 steps found)
- glycine betaine biosynthesis III (plants) (2/3 steps found)
- β-alanine biosynthesis I (1/2 steps found)
- β-alanine biosynthesis IV (1/2 steps found)
- choline degradation IV (2/4 steps found)
- dimethylsulfoniopropanoate biosynthesis I (Wollastonia) (1/3 steps found)
- dimethylsulfoniopropanoate biosynthesis II (Spartina) (1/4 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (490 amino acids)
>IAI47_08650 betaine-aldehyde dehydrogenase (Pantoea sp. MT58) MSRFTEQKLYIDGAYVAAASGETFQTINPVNGEVLAEVHAAGQEDVNRAVAAARKGQKVW AAMTAMERSRILRRAVDILRERNDALAELEMLDTGKPYSETSAVDIVTGADVLEYYAGLV PALEGQQIPLRETSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEV TPLTALKLAEIYTEAGVPDGVFNVLPGIGSVTGQLLTEHPGIDKVSFTGGVVSGKKVMAN AAGSTLKEVTMELGGKSPLIIFDDADLDLAADIAMMANFYSSGQVCTNGTRVFIPAKLKA AFEAKISERVARIQAGDLRDPATNFGPLVSFSHRDNVMRYIESGIAEGARLLCGGKRLTG GDFDQGAWVAPTVFTDCRDEMKIVREEIFGPVMSILSYETEEEVIRRANDTEFGLAAGLV TQDLNKAHRVIHQIEAGICWINTWGESAAEMPVGGYKHSGIGRENGLMTLQSYTQVKSVQ VELTRFQSVF