Protein Info for IAI47_08470 in Pantoea sp. MT58

Annotation: murein DD-endopeptidase MepM

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 443 transmembrane" amino acids 21 to 40 (20 residues), see Phobius details PF08525: OapA_N" amino acids 12 to 39 (28 residues), 36.4 bits, see alignment (E = 8.9e-13) PF04225: OapA" amino acids 99 to 177 (79 residues), 32.7 bits, see alignment E=1.7e-11 PF01476: LysM" amino acids 101 to 144 (44 residues), 22.4 bits, see alignment 2.3e-08 PF19425: Csd3_N2" amino acids 183 to 304 (122 residues), 212.9 bits, see alignment E=2.5e-67 PF01551: Peptidase_M23" amino acids 316 to 410 (95 residues), 126.1 bits, see alignment E=1.3e-40

Best Hits

Swiss-Prot: 75% identical to MEPM_SHIFL: Murein DD-endopeptidase MepM (mepM) from Shigella flexneri

KEGG orthology group: None (inferred from 98% identity to pva:Pvag_1661)

MetaCyc: 75% identical to peptidoglycan endopeptidase MepM (Escherichia coli K-12 substr. MG1655)
3.4.-.-; 3.4.-.-

Predicted SEED Role

"Cell wall endopeptidase, family M23/M37"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (443 amino acids)

>IAI47_08470 murein DD-endopeptidase MepM (Pantoea sp. MT58)
MQQIARSVALAFNNLPRPHRVMLGSLTVVTLAVAVWRPYVYHPTDDVTPIVKNIELDKNT
LRTLLPEASEPIDQSTPEPDEELPADDVDTDAPEMAGVHDYTVSSGDTLSSALNQYGIDI
SDINALVVSDRDLRNLQVGQQLSWTLDDDGGLKTLSWEISRRETRTYERTPSGGFKMEAE
MQKGEWRNSVMQGEVRGSFAASAMRAGLSSAEASAVIKAMQWQMDFRKLRAGDQFSVLMS
REMLEGKSAQSQLLGVRLRSGGKDYYAFRAEDGKFYDRNGSGLARGFMRFPTVKQYRVSS
NFNPRRLNPVTGRIAPHKGVDFALPIGTPVLAVGDGEVVVAKNGGAAGNYVAIRHGRQYM
TRYMHMKKVLVKPGEKVKRGDRIGLSGNTGRSTGPHLHFEIWINNQAVNPLTAKLPRMEG
LTGKDRSDYMAQVKAWLPQLGLK