Protein Info for IAI47_07035 in Pantoea sp. MT58

Annotation: NADP-dependent phosphogluconate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03446: NAD_binding_2
  • amino acids 5 to 174 (170 residues), 173.5 bits, E=3.7e-55
• TIGR00873: 6-phosphogluconate dehydrogenase (decarboxylating)
  • amino acids 5 to 468 (464 residues), 756.4 bits, E=5.8e-232
• PF00393: 6PGD
  • amino acids 179 to 467 (289 residues), 446 bits, E=6.5e-138

Best Hits

Swiss-Prot: 88% identical to 6PGD_ECOLI: 6-phosphogluconate dehydrogenase, decarboxylating (gnd) from Escherichia coli (strain K12)

KEGG orthology group: K00033, 6-phosphogluconate dehydrogenase [EC: 1.1.1.44] (inferred from 99% identity to pva:Pvag_1962)

MetaCyc: 88% identical to 6-phosphogluconate dehydrogenase, decarboxylating (Escherichia coli K-12 substr. MG1655)
Phosphogluconate dehydrogenase (decarboxylating). [EC: 1.1.1.44]

Predicted SEED Role

"6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" in subsystem Pentose phosphate pathway (EC 1.1.1.44)

MetaCyc Pathways

• superpathway of glucose and xylose degradation (16/17 steps found)
• pentose phosphate pathway (8/8 steps found)
• pentose phosphate pathway (oxidative branch) I (3/3 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• Glutathione metabolism
• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.44

Protein Sequence (469 amino acids)

>IAI47_07035 NADP-dependent phosphogluconate dehydrogenase (Pantoea sp. MT58)
MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKTDEVIAENQGKKLAPFYTVEEF
VESLEKPRRILLMVQAGEATDKTIASLTPHLDKGDILIDGGNTFYKDTIRRNKELSDQGF
NFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILDKIAARAEDGEACVAYIGPDGAGH
YVKMVHNGIEYGDMQLIAEAYALLKGALGLNNEELAETFTEWNNGELSSYLIDITKDIFT
KKDEEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLITESVFARYLSSLKTQRVAAS
KVLSGPQAKAFTGDKAEFIKKVRRALYLGKIVSYAQGFSQLRAASEENNWDLHYGEIAKI
FRAGCIIRAQFLQKITDAYEADAGIANLLLAPYFKDIADQYQQALRDVVSYAIQNGIPTP
TFSAAIAYYDSYRSEVLPANLIQAQRDYFGAHTYKRIDKDGVFHTEWLD