Protein Info for IAI47_06325 in Pantoea sp. MT58
Annotation: acetate kinase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 89% identical to ACKA_ECOLI: Acetate kinase (ackA) from Escherichia coli (strain K12)
KEGG orthology group: K00925, acetate kinase [EC: 2.7.2.1] (inferred from 98% identity to pva:Pvag_2113)MetaCyc: 89% identical to acetate kinase (Escherichia coli K-12 substr. MG1655)
Acetate kinase. [EC: 2.7.2.1, 2.7.2.14, 2.7.2.15, 2.7.2.7]; 2.7.2.15,2.7.2.1 [EC: 2.7.2.1, 2.7.2.14, 2.7.2.15, 2.7.2.7]
Predicted SEED Role
"Acetate kinase (EC 2.7.2.1)" in subsystem Ethanolamine utilization or Fermentations: Lactate or Fermentations: Mixed acid or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate or Threonine anaerobic catabolism gene cluster (EC 2.7.2.1)
MetaCyc Pathways
- hexitol fermentation to lactate, formate, ethanol and acetate (17/19 steps found)
- Bifidobacterium shunt (14/15 steps found)
- mixed acid fermentation (14/16 steps found)
- superpathway of N-acetylneuraminate degradation (18/22 steps found)
- superpathway of L-threonine metabolism (15/18 steps found)
- L-threonine degradation I (6/6 steps found)
- pyruvate fermentation to acetate II (3/3 steps found)
- pyruvate fermentation to acetate IV (3/3 steps found)
- superpathway of acetate utilization and formation (3/3 steps found)
- acetate and ATP formation from acetyl-CoA I (2/2 steps found)
- superpathway of fermentation (Chlamydomonas reinhardtii) (7/9 steps found)
- acetylene degradation (anaerobic) (4/5 steps found)
- ethanolamine utilization (4/5 steps found)
- pyruvate fermentation to acetate and (S)-lactate I (3/4 steps found)
- pyruvate fermentation to acetate I (2/3 steps found)
- pyruvate fermentation to acetate VII (2/3 steps found)
- glycine degradation (reductive Stickland reaction) (1/2 steps found)
- (S)-propane-1,2-diol degradation (3/5 steps found)
- pyruvate fermentation to acetate and lactate II (2/4 steps found)
- purine nucleobases degradation II (anaerobic) (16/24 steps found)
- reductive glycine pathway of autotrophic CO2 fixation (5/9 steps found)
- superpathway of Clostridium acetobutylicum acidogenic fermentation (5/9 steps found)
- lactate fermentation to acetate, CO2 and hydrogen (Desulfovibrionales) (4/8 steps found)
- acetyl-CoA fermentation to butanoate (3/7 steps found)
- pyruvate fermentation to butanoate (3/7 steps found)
- methanogenesis from acetate (2/6 steps found)
- superpathway of L-alanine fermentation (Stickland reaction) (4/9 steps found)
- L-lysine fermentation to acetate and butanoate (4/10 steps found)
- (S)-lactate fermentation to propanoate, acetate and hydrogen (5/13 steps found)
- purine nucleobases degradation I (anaerobic) (6/15 steps found)
- gallate degradation III (anaerobic) (3/11 steps found)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (7/17 steps found)
- L-glutamate degradation VII (to butanoate) (3/12 steps found)
- superpathway of methanogenesis (2/21 steps found)
- superpathway of L-lysine degradation (12/43 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.7.2.1 or 2.7.2.14 or 2.7.2.15 or 2.7.2.7
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (400 amino acids)
>IAI47_06325 acetate kinase (Pantoea sp. MT58) MSSKLVLVLNCGSSSLKFAILNPASGEEFLSGLAECFHLPEARIKWKLEGEKQEAPLGAG AAHSEALNFIVKSILAQKPELSAQIAAIGHRIVHGGEKLTQSVIITEKVVQGIKDASSFA PLHNPAHLIGIDEAMKNFPHLSDKNVAVFDTAFHQTMPEESYLYALPYKLYKEHGVRRYG AHGTSHFYVTHEAAKMLNKPLASLNIITCHLGNGGSVSAIRNGECVDTSMGLTPLEGLVM GTRSGDIDPAIVFFLHDTLGMSVDAINKLLTKESGLLGLTEVTSDCRYVEDNYSTKEDAK RAMDVFCHRLAKYIGSYTALMDGRLDAVVFTGGIGENAAMVRELSLKKLALLGFEVDHDR NLAARFGKSGYINKEGTRPALVIPTNEELVIAQDAARLTA