Protein Info for IAI47_06310 in Pantoea sp. MT58

Annotation: glutathione transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02798: GST_N
  • amino acids 13 to 80 (68 residues), 40.7 bits, E=5e-14
• PF13417: GST_N_3
  • amino acids 15 to 86 (72 residues), 51.4 bits, E=2.3e-17
• PF13409: GST_N_2
  • amino acids 15 to 82 (68 residues), 56.5 bits, E=6.7e-19
• PF14834: GST_C_4
  • amino acids 95 to 211 (117 residues), 164.1 bits, E=3.1e-52

Best Hits

Swiss-Prot: 62% identical to YFCF_ECOLI: Glutathione S-transferase YfcF (yfcF) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 96% identity to pva:Pvag_2116)

MetaCyc: 62% identical to glutathione S-transferase YfcF (Escherichia coli K-12 substr. MG1655)
Glutathione transferase. [EC: 2.5.1.18]

Predicted SEED Role

"Probable glutathione S-transferase (EC 2.5.1.18), YfcF homolog" in subsystem Glutathione: Non-redox reactions (EC 2.5.1.18)

MetaCyc Pathways

• 4-hydroxy-2-nonenal detoxification (1/4 steps found)
• glutathione-mediated detoxification I (3/8 steps found)
• pentachlorophenol degradation (3/10 steps found)
• gliotoxin biosynthesis (2/9 steps found)
• glutathione-mediated detoxification II (1/9 steps found)
• indole glucosinolate activation (intact plant cell) (3/12 steps found)
• camalexin biosynthesis (2/12 steps found)

KEGG Metabolic Maps

• Drug metabolism - cytochrome P450
• Glutathione metabolism
• Metabolism of xenobiotics by cytochrome P450

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.18

Use Curated BLAST to search for 2.5.1.18

Protein Sequence (213 amino acids)

>IAI47_06310 glutathione transferase (Pantoea sp. MT58)
MNYPPITLWSDSSFFSPYAMSAYVALNEKGIPFHLKRVDLSQNQQYAAAYRELSLTCRVP
TLQIDDFLLSESSAITEYLEERFPAPEFERLYPRDREKRARAREIQAWLRSDFLWIRQER
PTEVLFAGERFAPLTASAQQAVDKLVTAVERLLPDGQQNLFGEWSIADTDLAVMLNRLVL
HGDPLPARLQQYAEFQWQRASVQLWLAESGKNR