Protein Info for IAI47_05310 in Pantoea sp. MT58

Annotation: multidrug efflux RND transporter permease AcrD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1038 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 387 (22 residues), see Phobius details amino acids 393 to 413 (21 residues), see Phobius details amino acids 440 to 460 (21 residues), see Phobius details amino acids 471 to 495 (25 residues), see Phobius details amino acids 540 to 558 (19 residues), see Phobius details amino acids 872 to 890 (19 residues), see Phobius details amino acids 897 to 917 (21 residues), see Phobius details amino acids 923 to 947 (25 residues), see Phobius details amino acids 971 to 991 (21 residues), see Phobius details amino acids 1004 to 1026 (23 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1035 (1035 residues), 1743.6 bits, see alignment E=0 PF00873: ACR_tran" amino acids 1 to 1027 (1027 residues), 1369.8 bits, see alignment E=0 PF03176: MMPL" amino acids 319 to 514 (196 residues), 31 bits, see alignment E=1.9e-11 amino acids 868 to 1030 (163 residues), 21.1 bits, see alignment E=2e-08

Best Hits

Swiss-Prot: 80% identical to ACRD_ECOLI: Probable aminoglycoside efflux pump (acrD) from Escherichia coli (strain K12)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 62% identity to abo:ABO_0964)

MetaCyc: 63% identical to multidrug efflux pump RND permease AcrF (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-367

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1038 amino acids)

>IAI47_05310 multidrug efflux RND transporter permease AcrD (Pantoea sp. MT58)
MSNFFIDRPIFAWVLAILLCLCGTLSIISLPVEQYPDLAPPNVRITANYPGASAETLENT
VTQVIEQNMTGIDNLMYMSSNSSNTGQAQITLTFTAGTNPDEARQQVQNQLQSALRKLPQ
AVQSQGVTVNKTGDSNILMVAFVSTDGSMDKQDISDYVASNIQDPLSRIDGVGQVDAYGS
QYAMRIWLDPNKLIAYALTTDDVVNAIQSQNTQVAVGQVGGLPSVEKQALNATVNAQSML
QTPEQFRAITLKNNPDGSVVTLGDVATVALGAEKYDYLSRYNGQPASGLGVKLASGANEM
NTDKLVRARIEELSHYFPHGLEAKIAYETSPFVKASITDVVKTLLEAIVLVFGVMYLFMQ
NFRATLIPTIAVPVVLFGTFSVLYAFGFSINTLTMFAMVLAIGLLVDDAIVVVENVERIM
HEEGLSPRAATRKSMGQIQGALVGIALVLSAVFVPMAFFGGTVGAIYRQFSITIVSAMVL
SVLVAMILTPALCATLLKPAAQGEVHERRGFFGWFNRHFNRNADRYERGVAGILRTGGRW
LLVYVAIIGLMAFLFLRLPTSFLPLEDRGVFLTQVQLPAGATLEQTASVVAKVENYYLTK
EKANVLSVFSTIGAGPGGNGQNVARLFVRLKDWEARPGADRTSFAIIDRATKAFQKIKEG
RVIASSPPAITGMGSSSGFDMELQDHAGIGHTQLMAMRDKLLEMAGNDKSLSRVRHNGLD
DSPQLQIDVDARKAQALGVSLDTINDTMTTAWGSTYVNDFLDRGRVKKVYVQAAAEFRML
PDDVNKWYVRNSSGKMVPFSAFATSRWETGSPRLERYNGYSSLEIVGEAANGVSSGTAMD
EMEKLVNALPLGVGFQWTGASYQERLSGSQAPALYAISLLVVFLCLAALYESWSIPFSVM
LVVPLGVVGALIATWLRGLENDVYFQVGLLTVVGLSAKNAILIVEFANEINSKGRELVES
TLEASRQRLRPILMTSLAFIFGVLPMAISSGAGSGSQHAVGTGVMGGMISATLLAIFFVP
LFFVLVRRRFPLKEKPLD