Protein Info for IAI47_05275 in Pantoea sp. MT58

Annotation: phosphoribosylaminoimidazolesuccinocarboxamide synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00081: phosphoribosylaminoimidazolesuccinocarboxamide synthase
  • amino acids 3 to 235 (233 residues), 266.8 bits, E=1.2e-83
• PF01259: SAICAR_synt
  • amino acids 7 to 231 (225 residues), 257.6 bits, E=6.2e-81

Best Hits

Swiss-Prot: 91% identical to PUR7_ENT38: Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC) from Enterobacter sp. (strain 638)

KEGG orthology group: K01923, phosphoribosylaminoimidazole-succinocarboxamide synthase [EC: 6.3.2.6] (inferred from 99% identity to pva:Pvag_2234)

MetaCyc: 88% identical to phosphoribosylaminoimidazole-succinocarboxamide synthase (Escherichia coli K-12 substr. MG1655)
Phosphoribosylaminoimidazolesuccinocarboxamide synthase. [EC: 6.3.2.6]

Predicted SEED Role

"Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)" in subsystem De Novo Purine Biosynthesis (EC 6.3.2.6)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (46/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (26/26 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• inosine-5'-phosphate biosynthesis I (6/6 steps found)
• inosine-5'-phosphate biosynthesis II (5/5 steps found)
• inosine-5'-phosphate biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.2.6

Protein Sequence (237 amino acids)

>IAI47_05275 phosphoribosylaminoimidazolesuccinocarboxamide synthase (Pantoea sp. MT58)
MQKRAELYRGKAKTVYSTDNPDLLILEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTK
LQEAGIPTQMEALLSDTEALVKKLEMVPVECVVRNRAAGSLVKRLGVEEGIVLNPPLFDL
FLKDDEKHDPMVNESYCETFGWVSKQNLARMQELTFKANEVLSKLFDDAGLILVDFKLEF
GLFNGEVTLGDEFSPDGARLWDKETLDKMDKDRFRQSLGGVVEAYEAVAQRLGVKLD