Protein Info for IAI47_05260 in Pantoea sp. MT58

Annotation: glycine cleavage system transcriptional repressor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 231 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details PF13740: ACT_6" amino acids 45 to 120 (76 residues), 85.2 bits, see alignment E=1.2e-28

Best Hits

Swiss-Prot: 71% identical to GCVR_ECOLI: Glycine cleavage system transcriptional repressor (gcvR) from Escherichia coli (strain K12)

KEGG orthology group: K03567, glycine cleavage system transcriptional repressor (inferred from 96% identity to pva:Pvag_2237)

Predicted SEED Role

"Glycine cleavage system transcriptional antiactivator GcvR" in subsystem Glycine cleavage system or Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (231 amino acids)

>IAI47_05260 glycine cleavage system transcriptional repressor (Pantoea sp. MT58)
MVRFTLREKQASHAIPALVSSFFYVYLMVISESRGKAILPQSQPHHLVITALGVDRPGIV
NTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGSWNAITLIESTLPLKGAELELLIVMK
RTNARLRPPMPDTAFIQVEVADSPHIIERFTDLIDKHQMNVAELVSRITPAQHELPPTLY
IQMTAHSPTRTRGTSFEQAFNTLCQELNAQGTLRLYSVSDADSSEPVSAIR