Protein Info for IAI47_05085 in Pantoea sp. MT58

Annotation: glucose/quinate/shikimate family membrane-bound PQQ-dependent dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 813 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 41 to 61 (21 residues), see Phobius details amino acids 67 to 84 (18 residues), see Phobius details amino acids 90 to 114 (25 residues), see Phobius details amino acids 126 to 146 (21 residues), see Phobius details TIGR03074: membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family" amino acids 18 to 810 (793 residues), 1089 bits, see alignment E=0 PF13360: PQQ_2" amino acids 190 to 260 (71 residues), 19.7 bits, see alignment E=5.8e-08 amino acids 687 to 772 (86 residues), 28.5 bits, see alignment E=1.2e-10 PF01011: PQQ" amino acids 230 to 259 (30 residues), 23.4 bits, see alignment (E = 3.7e-09) amino acids 375 to 402 (28 residues), 21.5 bits, see alignment (E = 1.5e-08) amino acids 457 to 483 (27 residues), 28.3 bits, see alignment (E = 1e-10) amino acids 738 to 774 (37 residues), 31.7 bits, see alignment (E = 8.8e-12)

Best Hits

Swiss-Prot: 66% identical to QUIA_ACIAD: Quinate/shikimate dehydrogenase (quinone) (quiA) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

KEGG orthology group: K05358, quinate dehydrogenase (quinone) [EC: 1.1.5.8] (inferred from 86% identity to pao:Pat9b_2923)

MetaCyc: 66% identical to quinate/shikimate dehydrogenase (quinone) (Acinetobacter baylyi ADP1)
1.1.99.25-RXN [EC: 1.1.5.8]; 1.1.5.8 [EC: 1.1.5.8]

Predicted SEED Role

"Quinate/shikimate dehydrogenase [Pyrroloquinoline-quinone] (EC 1.1.99.25)" in subsystem Chorismate Synthesis or Quinate degradation (EC 1.1.99.25)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.5.8 or 1.1.99.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (813 amino acids)

>IAI47_05085 glucose/quinate/shikimate family membrane-bound PQQ-dependent dehydrogenase (Pantoea sp. MT58)
MAETSSRAGKGLGIASMLLGLVLLATGLFFAIGGGKLVALGGSWYFLIAGIVTVLSAIQF
FRRKSSAVVLFLLVFAGTLIWSLFDAGLDFWPLVSRLMVPAGLTLLAFLIWPSLRKHEGK
HSLAKPSYAFAAVLAAGMVATLVQMFQPHPTVAATGEELPLIPVDKAKQQKDWDNYGNTP
QGSRFVALDQITRDNVKDLQVAWTFRTGDTPVSPTGNGAEDQQTPLQIGNTLYLCTPHNN
VIAVEANTGKQLWKREINAQAEVWPRCRGLAYFDATKPVQQPDKPGSVPVTAAVLPAGDS
CQRRILMNTIDARLIAINADNGEFCEDFGNHGIVDLKAGLGQAPDPQYQLTSAPTLAGTT
VVVGGRVADNVQTDMPGGVLRGFDVITGKMRWAFDPGNVDPNAILMPGKDYTRSTPNSWA
PMSYDPAMNTVFIPMGSSSVDLWGANRTALDHKYGASVLALDATTGKEKWVYQTVHNDLW
DFDLPMQPSLIDFPQKDGSTTPAVVIGGKTGMIFVLDRMTGKPLTKVEELPMPQGHIPNE
QYTKTQPHSTGMPQIGNQTLKESDMWGATPFDQLACRIGFKSMRYDGLFTVPDTDKSLSF
PGSLGGMNWGSMSIDPNNHLLFVNDMRLGLWVQMIPADTNKTARGSNGGEAINTGMGAVP
LKGTPYAVNKNRFMSPLGIPCQKPPFGTLSAIDLKTQKIVWQVPVGTVQDTGPFGIKMRV
KMPIGMPTLGGTLATQGGLVFIAGTQDYYLRAFDASTGKEVWKARLPVGSQGGPMSYVSP
KDGKQYILISAGGARQSPDRGDYVIAYALPDSK