Protein Info for IAI47_05010 in Pantoea sp. MT58

Annotation: aminopeptidase PepB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF12404: DUF3663
  • amino acids 6 to 82 (77 residues), 113.8 bits, E=3e-37
• PF00883: Peptidase_M17
  • amino acids 110 to 422 (313 residues), 344 bits, E=8.6e-107

Best Hits

Swiss-Prot: 77% identical to PEPB_SHIF8: Peptidase B (pepB) from Shigella flexneri serotype 5b (strain 8401)

KEGG orthology group: K07751, PepB aminopeptidase [EC: 3.4.11.23] (inferred from 97% identity to pva:Pvag_2288)

MetaCyc: 77% identical to aminopeptidase B (Escherichia coli K-12 substr. MG1655)
Cytosol nonspecific dipeptidase. [EC: 3.4.13.18]; PepB aminopeptidase. [EC: 3.4.13.18, 3.4.11.23]

Predicted SEED Role

"Peptidase B (EC 3.4.11.23)" (EC 3.4.11.23)

MetaCyc Pathways

• muropeptide degradation (4/4 steps found)
• γ-glutamyl cycle (5/6 steps found)
• glutathione degradation (DUG pathway) (2/2 steps found)

KEGG Metabolic Maps

• Glutathione metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.23 or 3.4.13.18

Protein Sequence (428 amino acids)

>IAI47_05010 aminopeptidase PepB (Pantoea sp. MT58)
MTTQPMNITLSSQPADARWGEKAILSSNDSGMTLHLTGADALNTIQRAAHKIDGQGIRHV
ALTGEGWHLEQCWAFWQGFRGPKGQRQVDWPELGEHEQAEFDRRLKIIDWVRNVINLPAE
DLGPEQLAHNAVDLISEVGGDAVSYRITKGDELRVQGYMGLHTVGRGSNRPPVYLALDYN
PTGDENAPVYACLVGKGITFDTGGYSLKQSSFMDSMKSDMGGAATVTGALAMAISRGLNK
RVKLYLCCADNMVSSNAFKLGDIIRYRNGKSVEVMNTDAEGRLVLADGLIDASEQNPTMI
IDAATLTGAAKTALGNDYHALFTFDEVMAQSLMGSAVSENEPFWRLPLAEFHRSHLPSNF
ADLNNIASPSHAAGASSAAAFLSHFVSNYQQGWLHIDCSATYRKGAVDQWAAGATGLGVR
TLANLLLK