Protein Info for IAI47_04435 in Pantoea sp. MT58

Annotation: ATP-dependent chaperone ClpB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 861 TIGR03346: ATP-dependent chaperone protein ClpB" amino acids 10 to 858 (849 residues), 1452.8 bits, see alignment E=0 PF02861: Clp_N" amino acids 21 to 72 (52 residues), 45.6 bits, see alignment 3.1e-15 amino acids 98 to 149 (52 residues), 45.5 bits, see alignment 3.4e-15 PF00004: AAA" amino acids 207 to 340 (134 residues), 49.4 bits, see alignment E=3.3e-16 amino acids 606 to 729 (124 residues), 38.5 bits, see alignment E=7.7e-13 PF17871: AAA_lid_9" amino acids 347 to 447 (101 residues), 118.4 bits, see alignment E=6.6e-38 PF07724: AAA_2" amino acids 600 to 764 (165 residues), 232.2 bits, see alignment E=1.8e-72 PF00158: Sigma54_activat" amino acids 604 to 724 (121 residues), 24.2 bits, see alignment E=1.3e-08 PF07728: AAA_5" amino acids 605 to 725 (121 residues), 47.9 bits, see alignment E=7.2e-16 PF10431: ClpB_D2-small" amino acids 770 to 849 (80 residues), 102.4 bits, see alignment E=5.6e-33

Best Hits

Swiss-Prot: 88% identical to CLPB_SALTY: Chaperone protein ClpB (clpB) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03695, ATP-dependent Clp protease ATP-binding subunit ClpB (inferred from 78% identity to aap:NT05HA_1760)

MetaCyc: 88% identical to protein disaggregase ClpB (Escherichia coli K-12 substr. MG1655)
RXN185E-10

Predicted SEED Role

"ClpB protein" in subsystem Protein chaperones or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (861 amino acids)

>IAI47_04435 ATP-dependent chaperone ClpB (Pantoea sp. MT58)
MGGIMRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLKQEGGSVSPLLTSAGVD
VTPFRAQVEQAIDRLPQVEGSEGDVQPSSDLVRVLNLCDKLAQKRNDNFISSELFVLAAL
ESRGSLADLLKAAGATREKITGAIEQMRGGDNVNDQGAEDQRQALKKYTIDLTERAEKGK
LDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRR
VLALDMGALVAGAKYRGEFEERLKGVLSDLSKQEGNVILFIDELHTMVGAGKADGAMDAG
NMLKPALARGELHCVGATTLDEYRQYIEKDAALERRFQKVFVAEPGVEDTIAILRGLKER
YELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASSIRMQMDSKPESLDRLE
RRIIQLKLEQQALKKEADDASIKRLEMLETELNQKEREYAELEDEWKTEKASLSGTQNIK
AELEQARLNLEQARRQGDLAQMSELQYGKIPALEKQLAAATQAEGKTMKLLRNRVTDVEI
ADVLARWTGIPVARMMEGERDKLLRMEQDLHGRVIGQDEAVEAVSNAIRRSRAGLSDPNR
PIGSFLFLGPTGVGKTELCKSLANFLFDSDDAMVRIDMSEFMEKHSVSRLVGAPPGYVGY
EEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNSVVIM
TSNLGSDLIQERFGNLSYPEMKDIVMGVVGQHFRPEFVNRIDEVVVFHPLAEKHIASIAQ
IQLQRLYKRLDERGYQLHISDDAIKLLAENGYDPVYGARPLKRAIQQQIENPLAQQILAG
SLVPGKTIEMDVVNDVITAHQ