Protein Info for IAI47_03960 in Pantoea sp. MT58

Annotation: pitrilysin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 963 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF00675: Peptidase_M16" amino acids 56 to 192 (137 residues), 122.5 bits, see alignment E=2.1e-39 PF05193: Peptidase_M16_C" amino acids 217 to 393 (177 residues), 82.2 bits, see alignment E=6.4e-27 amino acids 684 to 859 (176 residues), 49 bits, see alignment E=1e-16 PF16187: Peptidase_M16_M" amino acids 401 to 672 (272 residues), 193.6 bits, see alignment E=6e-61

Best Hits

Swiss-Prot: 63% identical to PTRA_SHIFL: Protease 3 (ptrA) from Shigella flexneri

KEGG orthology group: K01407, protease III [EC: 3.4.24.55] (inferred from 70% identity to eay:EAM_2730)

MetaCyc: 63% identical to protease 3 (Escherichia coli K-12 substr. MG1655)
Pitrilysin. [EC: 3.4.24.55]

Predicted SEED Role

"Protease III precursor (EC 3.4.24.55)" (EC 3.4.24.55)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.24.55

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (963 amino acids)

>IAI47_03960 pitrilysin (Pantoea sp. MT58)
MRVHARWIAALMLSLVACTAQAQTSSGWQPVNDTIHKSEQDPRHYQAIRLDNGMTVLLVS
DPVAPKSLAALTLPIGSLDDPDQQAGLAHYLEHMVLMGSKHYPQPDNLAEFLKKHGGSHN
ASTASYRTAFYLEVENDSLEPAVDRLADAVAEPLLDPVNADRERHAVNAELTMARSRDGL
RMAQVGAETLNPAHPASRFSGGNLETLKDKPGSKLHQALLDFYHTHYSANLMKAVIYSNK
PLPEMASIAAKTFGRVQNHNASVPDITVPVVTDAQQGVIIHYVPAQPRKQLKIEFRIANN
SDRFRSKTDTLISYLISNRSKNTLTDWLQKQGLADGVNAGADPMTERNSGVFAITVSLTD
KGLAQRDDVVAAIFSYINLLRQQGDDKRYFDEVSHVLALDFRYPSITRDMDYIEWLVDTM
LRVPVEDTLDAPYLADQYDAAAIKSRLEEMTPQHARIWYISPQEPHNKTAYFVEAPYQVE
KITPQTFADWQQRASQISLAMPVLNPYIPDDFTLLPSDGKTYQHPVKLDNEDGMRIYWMP
SRYYASEPKAAITLALRNRHAISDARQQVLFGLNDYLSSLALDTLNSQASVGGISFSTGE
DDGLVFSASGFTQRLPTLLKKLVEGYATFQPTEQQLAQAKSWYLERLDAAEKGKAFEQAI
QPMQLLSQLPYTQRETRRKLVSTLTLKDVTTYRDSLFRDATPEMLVVGNLSAESVKQLGH
ELKQQVQSNATRDWHSQYVAIKKPMKANLQQQGSSTDSALAALYVPLGYSEYQSMAHSSM
LSQIVQPWFYNQLRTKEQLGYAVFAFQMPVGRQWGIGFLLQSNSKQPGWLLQRYQAFYPQ
AEKRLRSMSQADFVQYQQAMINDLQQRPQTLFEEADRYSRDFDRQNDLFNTRQKMAEQVA
RLTPASLADFFRQAVIEHKGMVMTSQIAGTGNGKVEFARQPGWKTWKELAKLQQSLPVKS
ETQ