Protein Info for IAI47_03560 in Pantoea sp. MT58

Annotation: A/G-specific adenine glycosylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 361 TIGR01084: A/G-specific adenine glycosylase" amino acids 6 to 276 (271 residues), 415.9 bits, see alignment E=4.2e-129 PF00730: HhH-GPD" amino acids 37 to 169 (133 residues), 96.3 bits, see alignment E=2.7e-31 PF00633: HHH" amino acids 101 to 128 (28 residues), 29.2 bits, see alignment (E = 1.2e-10) PF10576: EndIII_4Fe-2S" amino acids 193 to 209 (17 residues), 23.6 bits, see alignment (E = 1e-08) PF14815: NUDIX_4" amino acids 235 to 342 (108 residues), 77.4 bits, see alignment E=1.5e-25

Best Hits

Swiss-Prot: 76% identical to MUTY_ECOLI: Adenine DNA glycosylase (mutY) from Escherichia coli (strain K12)

KEGG orthology group: K03575, A/G-specific adenine glycosylase [EC: 3.2.2.-] (inferred from 98% identity to pva:Pvag_2572)

MetaCyc: 76% identical to adenine DNA glycosylase (Escherichia coli K-12 substr. MG1655)
RXN0-2661 [EC: 3.2.2.31]

Predicted SEED Role

"A/G-specific adenine glycosylase (EC 3.2.2.-)" in subsystem DNA repair, bacterial (EC 3.2.2.-)

Isozymes

Compare fitness of predicted isozymes for: 3.2.2.-

Use Curated BLAST to search for 3.2.2.- or 3.2.2.31

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (361 amino acids)

>IAI47_03560 A/G-specific adenine glycosylase (Pantoea sp. MT58)
MMQAPQFAQQVLDWYQRFGRKTLPWQLEKTPYKVWLSEVMLQQTQVATVIPYFERFMARF
PTVTDLAAAPLDEVLHLWTGMGYYARARNLHKAAKQIVEVHQGEFPRNFDDVSALPGVGR
STAGAILSLSLGQHFPILDGNVKRVLARCYAIGGWPGKKEVEKRLWQISEEVTPAEGVSQ
FNQAMMDLGALVCTRSKPKCEICPLNSGCEAYASSSWASYPGKKPKQVLPERSGWFLMMQ
DGDDVWLEQRPPVGLWGGLFCFPQFTTETALTDWLTARGIHAKPQQLTAFRHTFSHFHLD
IVPMWLSWPSAGAAMDEAGGLWYNLALPPSVGLAAPVERLLHELRHPRQLALDSCEINEE
E