Protein Info for IAI47_03125 in Pantoea sp. MT58

Annotation: glutathionylspermidine synthase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03738: GSP_synth
  • amino acids 12 to 383 (372 residues), 549 bits, E=3.2e-169

Best Hits

Swiss-Prot: 80% identical to YGIC_ECOLI: Putative acid--amine ligase YgiC (ygiC) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 98% identity to pva:Pvag_2652)

MetaCyc: 80% identical to peptide--spermidine ligase YgiC (Escherichia coli K-12 substr. MG1655)
6.3.1.-

Predicted SEED Role

"Similarity with glutathionylspermidine synthase (EC 6.3.1.8), group 1" in subsystem Glutathionylspermidine and Trypanothione (EC 6.3.1.8)

MetaCyc Pathways

• glutathionylspermidine biosynthesis (1/1 steps found)

KEGG Metabolic Maps

• Glutathione metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.1.8

Protein Sequence (386 amino acids)

>IAI47_03125 glutathionylspermidine synthase family protein (Pantoea sp. MT58)
MERIAISERPGWREKATEFGFRFHTMHGEPYWCEDAYYQFTLAQIEHLEDVTAELHQMCL
QVVDKVVNSEALLTKFRIPKHTWDFVRDSWHQRQPSLYSRLDLAWDGKGDVKLLENNADT
PTSLYEAAFFQWLWLEDQLNAGQLPAGSDQFNSLQEKLIERFAALHQQHGFNWLHFACCR
DTDEDRGTVQYLQDCATEAGLPSEFLYIDEIGLGEKGEFTDAQDQVISNLFKLYPWEFML
REMFSTKLGDAGVRWLEPAWKSIVSNKALLPLLWEMFPNHPNLLPAWFGEDDVPHMDKYV
VKPLFSREGANIRIVENGQEIARVDGPYGEEGMIVQQFHPLPKFGDSYTLIGSWLIDDQP
AGIGLREDRDLITQDLSRFYPHAFIG