Protein Info for IAI47_02315 in Pantoea sp. MT58

Annotation: shikimate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00507: shikimate dehydrogenase
  • amino acids 3 to 270 (268 residues), 317.6 bits, E=2.9e-99
• PF08501: Shikimate_dh_N
  • amino acids 6 to 88 (83 residues), 89.2 bits, E=2.5e-29
• PF01488: Shikimate_DH
  • amino acids 119 to 190 (72 residues), 39.7 bits, E=7.8e-14
• PF18317: SDH_C
  • amino acids 237 to 267 (31 residues), 42.7 bits, 5.6e-15

Best Hits

Swiss-Prot: 63% identical to AROE_CITK8: Shikimate dehydrogenase (NADP(+)) (aroE) from Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

KEGG orthology group: K00014, shikimate dehydrogenase [EC: 1.1.1.25] (inferred from 90% identity to pva:Pvag_2850)

MetaCyc: 61% identical to shikimate dehydrogenase (Escherichia coli K-12 substr. MG1655)
Shikimate dehydrogenase. [EC: 1.1.1.25]

Predicted SEED Role

"Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 1.1.1.25)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• superpathway of chorismate metabolism (44/59 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.25

Protein Sequence (272 amino acids)

>IAI47_02315 shikimate dehydrogenase (Pantoea sp. MT58)
MDQFAVFGNPISHSKSPLIHQVFAEQTGIEHRYGRICAPIDGFPQALSAFFEQGGRGANV
TLPFKQQAWEFADQLSERAALSGAVNTVKKLSDGQILGDNTDGIGLLSDLERLKMINAGD
NVLLVGAGGAARGVILPLLSAGVTLTVVNRTAARAEELATLFGENGPIRACRFEQLTGQH
FDLIVNATSSGVNGETPPLPSDVIHSGVQCYDMFYQSGLTPFLRWCQGHGTNHLADGLGM
LVGQAAHAFYIWHGVMPDIAPVIAQLKQAMQS