Protein Info for IAI47_01760 in Pantoea sp. MT58

Annotation: rhomboid family intramembrane serine protease GlpG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 273 transmembrane" amino acids 95 to 114 (20 residues), see Phobius details amino acids 136 to 158 (23 residues), see Phobius details amino acids 170 to 186 (17 residues), see Phobius details amino acids 192 to 211 (20 residues), see Phobius details amino acids 223 to 241 (19 residues), see Phobius details amino acids 246 to 265 (20 residues), see Phobius details TIGR04239: rhomboid family protease GlpG" amino acids 2 to 268 (267 residues), 385.6 bits, see alignment E=8.1e-120 PF12122: Rhomboid_N" amino acids 2 to 82 (81 residues), 93.1 bits, see alignment E=1.1e-30 PF01694: Rhomboid" amino acids 128 to 268 (141 residues), 100.9 bits, see alignment E=7.1e-33

Best Hits

Swiss-Prot: 65% identical to GLPG_ECO7I: Rhomboid protease GlpG (glpG) from Escherichia coli O7:K1 (strain IAI39 / ExPEC)

KEGG orthology group: K02441, GlpG protein (inferred from 98% identity to pva:Pvag_2964)

MetaCyc: 64% identical to rhomboid protease GlpG (Escherichia coli K-12 substr. MG1655)
Rhomboid protease. [EC: 3.4.21.105]

Predicted SEED Role

"GlpG protein (membrane protein of glp regulon)" in subsystem Glycerol and Glycerol-3-phosphate Uptake and Utilization

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.105

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (273 amino acids)

>IAI47_01760 rhomboid family intramembrane serine protease GlpG (Pantoea sp. MT58)
MRITQFNQPRMAQAFVDYMATQGITLRIEHENHYVIMLDDESKIAVVENELQQFLHDPNH
PRYQAASWHSGKTDSGLRYERSNIWANIRERAGPLTMTLMVLCIAVFILMQVMGDQAVMA
WLSWPDADQHLQVWRWFSHALLHFSLLHILFNLMWWWYLGGAVEKRLGSGKLFVIMLISA
LLSGWLQAKFSGIWFGGLSGVVYALMGYCWLRGERDPDSGVYLERGLIGFAVVWLVIGWF
GVFGLAIANAAHVAGLVVGLAMALVDTRNVTRR