Protein Info for IAI47_01740 in Pantoea sp. MT58

Annotation: triphosphoribosyl-dephospho-CoA synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03132: triphosphoribosyl-dephospho-CoA synthase MdcB
  • amino acids 13 to 278 (266 residues), 307.8 bits, E=3.5e-96
• PF01874: CitG
  • amino acids 17 to 276 (260 residues), 227.2 bits, E=1.6e-71

Best Hits

Swiss-Prot: 75% identical to MDCB_KLEPN: 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (mdcB) from Klebsiella pneumoniae

KEGG orthology group: K13930, triphosphoribosyl-dephospho-CoA synthase [EC: 2.7.8.25] (inferred from 93% identity to pva:Pvag_2969)

MetaCyc: 75% identical to 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (Klebsiella pneumoniae)
2.7.8.25-RXN [EC: 2.4.2.52]

Predicted SEED Role

"Triphosphoribosyl-dephospho-CoA synthetase (EC 2.7.8.25)" in subsystem Malonate decarboxylase (EC 2.7.8.25)

MetaCyc Pathways

• malonate decarboxylase activation (2/2 steps found)
• citrate lyase activation (1/5 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.52 or 2.7.8.25

Protein Sequence (286 amino acids)

>IAI47_01740 triphosphoribosyl-dephospho-CoA synthase (Pantoea sp. MT58)
MKLLSQTHAEAQASHLATIARDCLIDEARLSPKPGLVDSRGNGAHRDLTLALMERSAHSL
MPIFLALARHSWLRPADIALRETVGRLGRDGEQQMMAATGGVNTHRGAIWALGLLVSAAA
MQGGTTTADTLARTAAALASLPDSHAPRVFSKGLKATHRYQVPGAREEAQQAFPHVMKLA
LPQLLISRAVGASESEARLDALMAIMTSLSDTCVLSRAGMTGLDAMQQGARAVLLAGGCR
TAAGQRALQQLDRRMLALNASPGGAADLLAATLFIDRVCSPEHSYF