Protein Info for IAI47_01490 in Pantoea sp. MT58

Annotation: Gfo/Idh/MocA family oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 336 PF01408: GFO_IDH_MocA" amino acids 4 to 125 (122 residues), 97.7 bits, see alignment E=7.6e-32 PF02894: GFO_IDH_MocA_C" amino acids 137 to 327 (191 residues), 91.2 bits, see alignment E=9e-30

Best Hits

Swiss-Prot: 84% identical to IOLG_ERWT9: Inositol 2-dehydrogenase (iolG) from Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

KEGG orthology group: K00010, myo-inositol 2-dehydrogenase [EC: 1.1.1.18] (inferred from 100% identity to pva:Pvag_3022)

MetaCyc: 76% identical to myo-inositol 2-dehydrogenase (Klebsiella aerogenes)
Inositol 2-dehydrogenase. [EC: 1.1.1.18]

Predicted SEED Role

"Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)" in subsystem Inositol catabolism (EC 1.1.1.18)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.18

Use Curated BLAST to search for 1.1.1.18

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (336 amino acids)

>IAI47_01490 Gfo/Idh/MocA family oxidoreductase (Pantoea sp. MT58)
MTLKLGVIGTGAIGQEHIRRCSHVLQGAQVVAVSDINVEGARAALQRLNIEAEVFENGHD
VIQSPNVDAVLVTSWDPTHEEFTLAAIAAGKPVFCEKPLAMSAEGCRRVVDAEIQAGKRL
VQVGFMRPYDAGYRALKKVITDGDIGEPLMLHCAHRNPTVPENYTTPMAITNTLIHELDV
LRWLTNDDYKTVQVIFPRVTSKSHGQLKDPQIVLFETHKGVRIDVEIFVNCAYGYDIQCE
VVGEEGIARLPEPSSVQLRKDARLSNTILVDWKDRFIEAYDVELQAFINDIKAGQLTGPS
AWDGFAASVAADACIKAQNSGAIEPVEMPPRPAFYN