Protein Info for IAI47_01250 in Pantoea sp. MT58

Annotation: two-component system sensor histidine kinase KdbD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 891 transmembrane" amino acids 396 to 417 (22 residues), see Phobius details amino acids 420 to 420 (1 residues), see Phobius details amino acids 423 to 440 (18 residues), see Phobius details amino acids 446 to 468 (23 residues), see Phobius details amino acids 474 to 495 (22 residues), see Phobius details PF02702: KdpD" amino acids 21 to 228 (208 residues), 315.6 bits, see alignment E=4.2e-98 PF13493: DUF4118" amino acids 400 to 505 (106 residues), 98 bits, see alignment E=8.2e-32 PF13492: GAF_3" amino acids 525 to 641 (117 residues), 41.3 bits, see alignment E=5.9e-14 PF00512: HisKA" amino acids 661 to 727 (67 residues), 48 bits, see alignment 3.2e-16 PF02518: HATPase_c" amino acids 771 to 880 (110 residues), 94.2 bits, see alignment E=2.1e-30

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 76% identity to ebi:EbC_43370)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (891 amino acids)

>IAI47_01250 two-component system sensor histidine kinase KdbD (Pantoea sp. MT58)
MNHEPQRPDPDALLQANRETHRGQLKIYFGACAGVGKTYAMLQEAQRLRAQGLDVLIGVV
ETHERPETAQLLTGLTLLPRRATGRSRHAEFDLDAALARHPAVILMDELAHTNVKGSRHP
KRWQDIEELLEAGIDVLTTVNVQHLESLNDVVGGVTGIQVRETVPDPFFDSADEVVLVDL
PPDDLRQRLKEGKVYIGDRAERAIENFFRKGNLFALRELALRRTADRVDDQMRAWRDQQG
RDRVWHTRDAILLCIGDDSGSEKLVRTAARLAARLGSEWHAVYVETPRLNRLPEARRRAI
LRTLQLAQELGAETATLSEPDEAEAVLGYAREHNLGKIVTGRRPLRRWRRDSFAERLGQL
GPDLDLLVVALDEPLKDAPHPLPDGRVNSEKWRIQLRGVMMALVLCILVTAAGQSVLINF
DPANCVMIYLLAVVIVALRYGRWPSVIATVINIVAFDLFFVAPTGTVAVSDLQYLVTFGV
MLAVGVIVGNLTAGVRYQARVARYREQRARQLYEMAKSLGSALTPQDIAATSQRVLDATL
QARCLLLLPDEQGELKAVGDALPASEPDRAIAKWSYSKGQPAGAGTDTLPAVPYQILPLK
SGAQCRGLLVVEPQNLRQLMIPEQQRLVETFTVLIANALERMALSHSEAVSRLSAEREQL
RNALLSALSHDLRTPLTVLFGQAEMLMLDLASDNSKYVPQASQIREQTLSTIRLVSNMLD
MARIQSGGLNLREEWLALEEVIGGALSSMAPSLKGHEVQLDLPDDIVLIKGDSTLLERVF
TNLIENSLKYAGNSAPRGIRAWRAASRLEIAVWDGGPGIAEEDLTRIFDKFWRGNKESAV
PGVGLGLAICKTIIESHGGQIWAENRPEGGAAFRLSLPLPPAPEISDEGLK