Protein Info for IAI47_00845 in Pantoea sp. MT58

Annotation: HslU--HslV peptidase ATPase subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 445 TIGR00390: ATP-dependent protease HslVU, ATPase subunit" amino acids 4 to 445 (442 residues), 762 bits, see alignment E=1e-233 PF07728: AAA_5" amino acids 52 to 97 (46 residues), 25.9 bits, see alignment 2.6e-09 PF00004: AAA" amino acids 53 to 100 (48 residues), 30 bits, see alignment 2e-10 amino acids 240 to 334 (95 residues), 27.3 bits, see alignment E=1.3e-09 PF07724: AAA_2" amino acids 188 to 331 (144 residues), 98.4 bits, see alignment E=1.5e-31

Best Hits

Swiss-Prot: 90% identical to HSLU_SALCH: ATP-dependent protease ATPase subunit HslU (hslU) from Salmonella choleraesuis (strain SC-B67)

KEGG orthology group: K03667, ATP-dependent HslUV protease ATP-binding subunit HslU (inferred from 99% identity to pva:Pvag_3148)

MetaCyc: 90% identical to ATPase component of the HslVU protease (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"ATP-dependent hsl protease ATP-binding subunit HslU" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (445 amino acids)

>IAI47_00845 HslU--HslV peptidase ATPase subunit (Pantoea sp. MT58)
MSEMTPREIVSELNRFIIGQDSAKRAVAIALRNRWRRMQLDEELRHEVTPKNILMIGPTG
VGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDSAIKMVRSQAIEKNK
YRAEEMAEERILDVLIPPAKNNWGQAEQSAEPSAARQSFRKKLREGQLDDKEIEIDLAAS
SPGVEIMAPPGMEEMTSQLQSMFQNLGGQKQKARKLKIKEAMKLLIEEEAAKLVNPEELK
QDAIEAVEQHGIVFIDEIDKICKRGGQNAGGPDVSREGVQRDLLPLVEGCTVSTKHGMVK
TDHILFIASGAFQVASPSDLIPELQGRLPIRVELQALTVNDFQRILTEPNASITVQYKAL
MNTEGVNIEFTEEGIRRIAEAAWQVNETTENIGARRLHTVLERLMEDISYDASDRHGESF
TIDADYVAKHLDELVADEDLSRFIL