Protein Info for HSERO_RS22345 in Herbaspirillum seropedicae SmR1

Annotation: urea carboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1207 PF00289: Biotin_carb_N" amino acids 1 to 109 (109 residues), 138.4 bits, see alignment E=6.2e-44 TIGR02712: urea carboxylase" amino acids 2 to 1200 (1199 residues), 1856 bits, see alignment E=0 PF02786: CPSase_L_D2" amino acids 116 to 318 (203 residues), 210.5 bits, see alignment E=9.3e-66 PF07478: Dala_Dala_lig_C" amino acids 145 to 291 (147 residues), 43.9 bits, see alignment E=9e-15 PF02785: Biotin_carb_C" amino acids 338 to 447 (110 residues), 100.8 bits, see alignment E=2.2e-32 TIGR00724: biotin-dependent carboxylase uncharacterized domain" amino acids 454 to 774 (321 residues), 282.8 bits, see alignment E=2.9e-88 PF02626: CT_A_B" amino acids 478 to 754 (277 residues), 312.5 bits, see alignment E=1.2e-96 PF02682: CT_C_D" amino acids 804 to 1024 (221 residues), 137 bits, see alignment E=3.1e-43 PF00364: Biotin_lipoyl" amino acids 1136 to 1198 (63 residues), 55.5 bits, see alignment 1.9e-18

Best Hits

Predicted SEED Role

"Urea carboxylase (EC 6.3.4.6)" in subsystem Urea decomposition (EC 6.3.4.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See D8IVX9 at UniProt or InterPro

Protein Sequence (1207 amino acids)

>HSERO_RS22345 urea carboxylase (Herbaspirillum seropedicae SmR1)
MFDHLLIANRGAIACRILRTLRTLDVTGVCVYSEADLGSLHVLQADRAISLGEGPAAQTY
LAVDKILAAARDSGAQAIHPGYGFLSENAAFAEACEAAGIAFVGPTPAQLRIFGLKHTAR
ALAREQGVPMLEGTDLLESIDDALAAASRVGYPVMLKSTAGGGGIGMRVCRSDAELADAF
DSVRRLGQNNFSDAGVFIEKYIERARHLEVQVFGDGRGEVIALGVRDCSVQRRNQKVLEE
TPAPNLPDGMAEALCAAAIKLAKAVNYRSAGTVEFVYDSLAGQFYFLEVNTRLQVEHGVT
EQVWGVDLVRWMIELAAGDLPPLAQLAAGLQPRGHAIQARLYAEDPGRQFQPCPGLLTAV
DFPPVDGQALRIDTWVEAGCEIAPYFDPMIAKLISWQPTREAARLALDAALRATLLYGVE
TNQHYLRQILADVPFASGQPWTRCLEQLVYRADTVEVLAPGTQTTVQDHPGRIGYWAVGV
PPSGPMDERALRLGNRLLGNAEEAAGLEVTMSGPILRFNTAAMVVVTGAVIPVLLDGVAQ
PMATVLHIAAGSTLKLGAISGAGARSYLAVRGGVQVPTYLGSRSTFTLGQFGGHAGRALA
SGDILHLAPLAADAMTQAGQTLPAALYPALEAVRQVRVIYGPHGAPEYFTPAYMETFFAT
DWEVHFNSSRTGVRLIGPKPEWVRDSGGEAGLHPSNIHDNPYAVGAVDFTGDMPVILGPD
GPSLGGFVCPVTVIEADLWQIGQLKAGDKVRFVPVEVNTARRIALAAQAGVASLQPQPVD
WSPAPLASPIVLDLGQDERRLVARLSGDANLLLEVGSPQLDLVLRFRVHALITALEEQAL
PGVIDLTPGIRSLQVHYQPEALPLPTLLQTIAGLWDAVCASENLTVSSRIVHLPLSWDDP
ACQLAIEKYMTTVRKDAPWCPSNLEFIRRINDLKDIGAVRETVFDASYLVMGLGDVYLGA
PVATPLDPRHRLVTTKYNPARTWTAENSVGIGGAYLCIYGMEGPGGYQFVGRTLQMWNRY
REVAAFRGKPWLLRFFDQIRFYPVTAEELQTIRRDFPLGRFEVGIEETQLNLADYQDFLQ
READGIAAFRQHQQAAFDAERQRWIASGQANYESEESSAIAQEAAPLQDGQMAVDAPIAG
NLWQVKVSPGQRVAQGELLMILESMKMEIHIAAPAAGVVAEVRVQPGSPVRAGQCVLVME
DTEEEVA