Protein Info for HSERO_RS22125 in Herbaspirillum seropedicae SmR1

Annotation: glucosamine--fructose-6-phosphate aminotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 605 (604 residues), 832 bits, E=1.5e-254
• PF13522: GATase_6
  • amino acids 67 to 190 (124 residues), 76.7 bits, E=3.4e-25
• PF13537: GATase_7
  • amino acids 83 to 195 (113 residues), 64.2 bits, E=2.3e-21
• PF01380: SIS
  • amino acids 288 to 413 (126 residues), 99.1 bits, E=3.5e-32
  • amino acids 459 to 587 (129 residues), 81.9 bits, E=7.6e-27

Best Hits

Swiss-Prot: 82% identical to GLMS_BORBR: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (glmS) from Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 100% identity to hse:Hsero_4426)

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• chitin biosynthesis (5/9 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (12/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.16

Use Curated BLAST to search for 2.6.1.16

Sequence Analysis Tools

See D8IVT5 at UniProt or InterPro

Protein Sequence (605 amino acids)

>HSERO_RS22125 glucosamine--fructose-6-phosphate aminotransferase (Herbaspirillum seropedicae SmR1)
MCGIVGAVAQQNVTPILLEGLKRLEYRGYDSCGVALHVDGKLQRSRSTSRVAELQQQIAQ
SGLSGFTGIAHTRWATHGAPATHNAHPHFSRDRIALVHNGIIENHDELRAELQAVGYVFE
SQTDTEVIAHLVDHMYDGDLFNTVQQAVRRLTGAYAIAVFCADEPHRVVAARQGSPLIVG
VGEGQNFVASDAMALAGTTDQIIYLEEGDVVDLQLQKVWIVDAAGRPAEREVRTVQAYTS
AVELGPYQHYMQKEIFEQPRAIADTLEGVVGIMPELFGDKAYKVFKEIDSILILACGTSY
YAGLTAKYWLESIAKIPVNVEIASEYRYRDSVPNPKSLVVTISQSGETADTLAALKHARS
LGMQHTLTICNVATSAMVRECELAYITRAGVEVGVASTKAFTTQLAALFLLTLALAQTRG
LLTEEQEAEHLKAMRHLPAALQSVLALEPSIVAWAESFARRENALFLGRGLHYPIALEGA
LKLKEITYIHAEAYAAGELKHGPLALVTDQMPVVTIAPNDALVEKLKSNMQEVRARGGQL
YVFADGDSHISSAEGLHVIRMPEHYGVLSPILHVVPLQLLSYHTALARGTDVDKPRNLAK
SVTVE