Protein Info for HSERO_RS19190 in Herbaspirillum seropedicae SmR1

Annotation: glutamate-1-semialdehyde 2,1-aminomutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00713: glutamate-1-semialdehyde-2,1-aminomutase
  • amino acids 6 to 425 (420 residues), 624.4 bits, E=4.2e-192
• PF00202: Aminotran_3
  • amino acids 33 to 395 (363 residues), 266.9 bits, E=2.6e-83
• PF00155: Aminotran_1_2
  • amino acids 70 to 396 (327 residues), 24.1 bits, E=2e-09

Best Hits

Swiss-Prot: 79% identical to GSA_JANMA: Glutamate-1-semialdehyde 2,1-aminomutase (hemL) from Janthinobacterium sp. (strain Marseille)

KEGG orthology group: K01845, glutamate-1-semialdehyde 2,1-aminomutase [EC: 5.4.3.8] (inferred from 100% identity to hse:Hsero_3844)

MetaCyc: 61% identical to glutamate-1-semialdehyde 2,1-aminomutase (Escherichia coli K-12 substr. MG1655)
Glutamate-1-semialdehyde 2,1-aminomutase. [EC: 5.4.3.8]

Predicted SEED Role

"Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 5.4.3.8)

MetaCyc Pathways

• adenosylcobalamin biosynthesis II (aerobic) (29/33 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (29/36 steps found)
• superpathway of heme b biosynthesis from glutamate (9/10 steps found)
• tetrapyrrole biosynthesis I (from glutamate) (6/6 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.4.3.8

Sequence Analysis Tools

See D8IRX9 at UniProt or InterPro

Protein Sequence (427 amino acids)

>HSERO_RS19190 glutamate-1-semialdehyde 2,1-aminomutase (Herbaspirillum seropedicae SmR1)
MTKTNASLFARAQQSTPGGVNSPVRAFRSVGGTPRFIERAEGPWFWDAEGKRYIDYIGSW
GPAIVGHAHPEVIQAVQQAAARGLSFGAPTEAEIEMAEEIIKLVPSIEQIRLVSSGTEAT
MSALRLARGATGRDKIIKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPEDFAKHTLVL
DYNDAAQLEEAFKTAGNEIACVIVEPVAGNMNLVRASDEFLRTMRRLCTEYGAILIFDEV
MSGFRVARGGAQELNGIVPDLTALGKVIGGGLPVAAFGGRAEVMKHLAPLGGVYQAGTLS
GNPVTVAAGMATLKIIQQPDFYTNLSTQTRKLADGLAAAAQAAGVTFAADAIGGMFGLYF
DAKVPTSYAEVMQGDKERFNRFFHKMLDAGVYFAPSAFEAGFVSAQHSDAIIEETVAAAA
RAFSELG