Protein Info for HSERO_RS18855 in Herbaspirillum seropedicae SmR1

Annotation: sensor protein KdpD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 918 transmembrane" amino acids 409 to 427 (19 residues), see Phobius details amino acids 433 to 449 (17 residues), see Phobius details amino acids 455 to 472 (18 residues), see Phobius details amino acids 484 to 506 (23 residues), see Phobius details PF02702: KdpD" amino acids 23 to 231 (209 residues), 319.2 bits, see alignment E=2.7e-99 PF13493: DUF4118" amino acids 411 to 516 (106 residues), 108.9 bits, see alignment E=2.7e-35 PF13492: GAF_3" amino acids 536 to 667 (132 residues), 45.4 bits, see alignment E=2.7e-15 PF00512: HisKA" amino acids 687 to 752 (66 residues), 55.6 bits, see alignment 1.1e-18 PF02518: HATPase_c" amino acids 797 to 910 (114 residues), 96 bits, see alignment E=4.8e-31

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 100% identity to hse:Hsero_3776)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See D8IRC8 at UniProt or InterPro

Protein Sequence (918 amino acids)

>HSERO_RS18855 sensor protein KdpD (Herbaspirillum seropedicae SmR1)
MTTRPDPDDLLERVMRDEERQARGRLKIFFGFSAGVGKTFAMLEAAQALAAQGGDVVAGV
VETHGRAETEAQLAGLARLPMRMVAYRDRQLPEFDLDAALERKPGVILVDELAHSNVPGS
RHAKRWQDIDELLRAGIDVYTTLNVQHIESLNDVVGQITGIRVFETVPDHVFDEADDVML
VDIPPDELLARLQQGKVYLPQQAEKAGRNFFRKGNLIALREIALRRTADRVDADMRQYRA
DRSIAQLWQARECIVVAIGSGSGEERLIREAARLAAKLQAQWLAVHVDLPGQRQAMEARE
RVVSYLKLAHSLGAETASISGEELAAALLQFARSRNAGKLVIGQEEGGLRRLLRWPRGTL
AQRIARSGGEIDLYTIARSRTRHQHEPASPDSAASAAEALLTRRRRTRGTLWAVASCAIT
TTLAFLLDGKLHPANVIMLYLVGVMLVAMRYGRAASALVSVLSVLSFDFFFVDPRFSITV
SDAQYLLTLAVMLAVSLFISSLAARLRRQASVAMQREARAANLYMLGKELSALLTLDQIL
EIGRRHLAAVFGARIAFFLPDSADQLRLAEPEQDSGAAHVFRNVDAGVAQWVYDNGQAAG
KGTATLPSAAALYLPLTATMRTRGVLAFAIEAPSEEERQLAAAQLALPENRQMLEIFCSQ
IAMAIERLHYAEVAQDALVTMESERLRNSLLSAISHDLRTPLTSLVGSADVLAANARLDD
DARAMARTISEQSQKMVGLMNNLLDMARLQAGVVTLNRQWNALEELAGSALRLLAKALEG
RQVDTRIAPELPLLRVDAVLLERVLANLVENAIKYSPPGTPIGISAHVEHGDGAPQVKVC
VMDQGRGFPPTMTQHAFEKFTRGDNESATPGVGLGLAICRAIIEAHQGRIWIAPQEAGQG
ATVCFTLPVETQPAPPEE