Protein Info for HSERO_RS16465 in Herbaspirillum seropedicae SmR1

Annotation: acetyl-CoA carboxylase carboxyl transferase subunit beta

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00515: acetyl-CoA carboxylase, carboxyl transferase, beta subunit
  • amino acids 1 to 284 (284 residues), 423.1 bits, E=2.8e-131
• PF17848: zf-ACC
  • amino acids 27 to 52 (26 residues), 49.5 bits, see alignment (E = 3.9e-17)
• PF01039: Carboxyl_trans
  • amino acids 98 to 243 (146 residues), 63 bits, E=2.3e-21

Best Hits

Swiss-Prot: 83% identical to ACCD_CUPTR: Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD) from Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1)

KEGG orthology group: K01963, acetyl-CoA carboxylase carboxyl transferase subunit beta [EC: 6.4.1.2] (inferred from 100% identity to hse:Hsero_3290)

MetaCyc: 64% identical to acetyl-CoA carboxyltransferase subunit beta (Escherichia coli K-12 substr. MG1655)
RXN0-5055 [EC: 2.1.3.15]

Predicted SEED Role

"Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2)" in subsystem Fatty Acid Biosynthesis FASII (EC 6.4.1.2)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (50/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
• biotin-carboxyl carrier protein assembly (4/4 steps found)
• fatty acid biosynthesis initiation (type II) (3/3 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (13/17 steps found)
• superpathway of fatty acid biosynthesis initiation (4/5 steps found)
• fatty acid biosynthesis initiation (type I) (1/3 steps found)
• propanoyl CoA degradation I (1/3 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (6/10 steps found)
• 2-oxobutanoate degradation I (1/4 steps found)
• candicidin biosynthesis (1/6 steps found)
• jadomycin biosynthesis (3/9 steps found)
• 3-hydroxypropanoate cycle (5/13 steps found)
• glyoxylate assimilation (5/13 steps found)
• methylaspartate cycle (9/19 steps found)
• superpathway of candicidin biosynthesis (3/11 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (8/18 steps found)
• superpathway of L-methionine salvage and degradation (5/16 steps found)
• superpathway of the 3-hydroxypropanoate cycle (6/18 steps found)
• superpathway of mycolate biosynthesis (26/239 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis
• Propanoate metabolism
• Pyruvate metabolism
• Tetracycline biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 6.4.1.2

Use Curated BLAST to search for 2.1.3.15 or 6.4.1.2

Sequence Analysis Tools

See D8J1Y8 at UniProt or InterPro

Protein Sequence (289 amino acids)

>HSERO_RS16465 acetyl-CoA carboxylase carboxyl transferase subunit beta (Herbaspirillum seropedicae SmR1)
MSWLEKLLPPQIQRGSTSRKAIPEGLWVKCPSCEAVLYRTDLESNLHVCPKCSHHMRIRA
RARLDALLDEGGRYEIGQEALPVDTLKFKDSKKYPDRLKDAMESTGETDAMVVMGGAIMT
LPVVVACFEFEFMGGSMGSVVGERFVRGAQAALEQKVPFICITATGGARMQEGLLSLMQM
AKTTAMLTKLSEKKLPFISVLTDPTMGGVSASFAFMGDVVMAEPKALIGFAGPRVIENTV
REKLPEGFQRAEFLVTKGAIDMIVDRRKMREEIAHLLALLQNQAAETVS