Protein Info for HSERO_RS16325 in Herbaspirillum seropedicae SmR1

Annotation: aldehyde oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02965: xanthine dehydrogenase, molybdopterin binding subunit
  • amino acids 22 to 783 (762 residues), 1286.3 bits, E=0
• PF01315: Ald_Xan_dh_C
  • amino acids 36 to 143 (108 residues), 105.4 bits, E=3.1e-34
• PF02738: MoCoBD_1
  • amino acids 163 to 395 (233 residues), 265.9 bits, E=4e-83
• PF20256: MoCoBD_2
  • amino acids 428 to 712 (285 residues), 332 bits, E=5.5e-103

Best Hits

KEGG orthology group: K13482, xanthine dehydrogenase large subunit [EC: 1.17.1.4] (inferred from 100% identity to hse:Hsero_3263)

Predicted SEED Role

"Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)

MetaCyc Pathways

• adenosine nucleotides degradation II (4/5 steps found)
• guanosine nucleotides degradation II (3/4 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation II (aerobic) (8/11 steps found)
• ureide biosynthesis (5/7 steps found)
• adenosine nucleotides degradation I (5/8 steps found)
• guanosine nucleotides degradation I (2/4 steps found)
• superpathway of guanosine nucleotides degradation (plants) (3/6 steps found)
• purine nucleotides degradation I (plants) (7/12 steps found)
• purine nucleobases degradation II (anaerobic) (15/24 steps found)
• superpathway of purines degradation in plants (9/18 steps found)
• caffeine degradation III (bacteria, via demethylation) (1/7 steps found)
• theophylline degradation (1/9 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (1/10 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4

Sequence Analysis Tools

See D8J1W1 at UniProt or InterPro

Protein Sequence (789 amino acids)

>HSERO_RS16325 aldehyde oxidase (Herbaspirillum seropedicae SmR1)
MNQHTEAFLAPLAQPPHDWAAVGKPHPHESARLHVTGEAVYTDDIPELRGTLHAALGLSQ
KAHARVRAIDLEKVKAAPGVKAVFTAADIPGDNECGAILHDDPVLADGLVQYVGQPLFIV
VADSHELARRAARLAVIDYEELPAILTPRQAHAAQSYVLPPMHLSRGEPAIALALAPHRL
RGQFDVGGQEQFYLEGQISYAIPKEGRGMHVYCSTQHPSEMQHHVATVLGLASHDVLVEC
RRMGGGFGGKESQSALWACAAAVAAARLQRPVKLRADRDDDMMVTGKRHCFAYDYEIGYD
DHGRIVAAKIEMISRAGFSADLSGPVATRAVCHFDNAYYLSDVDIRAMCGKTNTQSNTAF
RGFGGPQGALAIEYIIDDIARHLGRDPLEIRRNNFYGPSDEEGPQARNVTHYGQKVEDNI
IPALVDQLERSSRYQERRQAVAAFNAGSTVLKKGLALTPVKFGISFNVPHLNQAGALVHV
YTDGSVLVNHGGTEMGQGLNTKVAQVVAHTLGVPLERVRCSATDTSKVANTSATAASTGS
DLNGKAAQDAALQVRTRLAQVAATLLGVEPTAVRFADGRVMAGAQSMAFAELVMKAYLQR
VQLWSDGFYSTPKVHWDAKRMHGHPFFYFAYAAAVSEVVIDTLTGEWKLLQADLLYDAGQ
SLNPALDIGQVEGGFIQGMGWLTTEELWWNKDGKLMTHAPSTYKIPAISDCPARLRTELF
QNRNVSDTIHRSKAVGEPPLLLPFSVFLAIRDAVSAVGGHRVNPPLRAPATSEAILDAVD
AVRAATASR