Protein Info for HSERO_RS15550 in Herbaspirillum seropedicae SmR1

Annotation: sulfite reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03460: NIR_SIR_ferr
  • amino acids 48 to 110 (63 residues), 65.7 bits, E=2.6e-22
  • amino acids 345 to 397 (53 residues), 50.3 bits, 1.6e-17
• PF01077: NIR_SIR
  • amino acids 119 to 273 (155 residues), 170.6 bits, E=1.9e-54
  • amino acids 411 to 547 (137 residues), 53.5 bits, E=2e-18

Best Hits

KEGG orthology group: K00381, sulfite reductase (NADPH) hemoprotein beta-component [EC: 1.8.1.2] (inferred from 100% identity to hse:Hsero_3099)

Predicted SEED Role

"Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2)" in subsystem Cysteine Biosynthesis (EC 1.8.1.2)

MetaCyc Pathways

• superpathway of L-methionine biosynthesis (by sulfhydrylation) (11/12 steps found)
• superpathway of sulfate assimilation and cysteine biosynthesis (8/9 steps found)
• assimilatory sulfate reduction III (3/3 steps found)
• assimilatory sulfate reduction I (3/4 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (6/10 steps found)

KEGG Metabolic Maps

• Sulfur metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.2

Use Curated BLAST to search for 1.8.1.2

Sequence Analysis Tools

See D8J0M7 at UniProt or InterPro

Protein Sequence (565 amino acids)

>HSERO_RS15550 sulfite reductase (Herbaspirillum seropedicae SmR1)
MYRYDQYDHLIVKERVAQYRDQVRRRLSDELAEDEFRILRLQNGLYLQRHAYMLRIAIPY
GMLASNQLRKFAEIAVKYDRGYGHFTTRQNIQFNWIKLEESPEILEQLASVEMHAIQTSG
NCIRNTTSDELAGVAADEIVDPRPYAELIREWSTFHPEFAYLPRKFKIAISGAAEDRAAT
AVHDIGLHVLKNEAGEVGFRVLVGGGMGRTPILGSVIRDFLPWQHAMSYLEAILRVYNQY
GRRDNMYKARIKILVKAIGPEEFARQVEEEWAQIKDGPSTLTEEELQRVAKFFTDPAYET
LPAVDAEYERLKAEDRGFANWIKRNVKAHKKAGYAAVVLSLKKPGVPPGDITADQMNFVA
DLADQYSFGELRVTHEQNLVLADVKQSELYALWQAAKSHGLATPNIGLLTDIICCPGGDF
CSLANAKSIPIAQAIAEKFENIDFQHDIGDIELNISGCINACGHHHVGNIGILGVDKDGS
EWYQVSLGGAQGNESSVGKIIGPSFSATQMPTVIDRLLQVYVQQRTEEERFIDTVRRIGV
TPFKEFVYATPIRSAEYVAGEDANA