Protein Info for HSERO_RS14995 in Herbaspirillum seropedicae SmR1

Annotation: cystathionine beta-lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01053: Cys_Met_Meta_PP
  • amino acids 12 to 389 (378 residues), 314.3 bits, E=4.4e-98
• TIGR01324: cystathionine beta-lyase
  • amino acids 13 to 391 (379 residues), 390.4 bits, E=3.5e-121

Best Hits

KEGG orthology group: K01760, cystathionine beta-lyase [EC: 4.4.1.8] (inferred from 100% identity to hse:Hsero_2990)

Predicted SEED Role

"Cystathionine beta-lyase (EC 4.4.1.8)" in subsystem Methionine Biosynthesis (EC 4.4.1.8)

MetaCyc Pathways

• hydrogen sulfide biosynthesis II (mammalian) (1/6 steps found)

KEGG Metabolic Maps

• Biosynthesis of plant hormones
• Cysteine metabolism
• Methionine metabolism
• Nitrogen metabolism
• Selenoamino acid metabolism
• Sulfur metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.4.1.8

Sequence Analysis Tools

See D8J0C2 at UniProt or InterPro

Protein Sequence (392 amino acids)

>HSERO_RS14995 cystathionine beta-lyase (Herbaspirillum seropedicae SmR1)
VSDPKQTSLTPQTSLVHSSYRAPDGFEAFPVGIHHASTVLFPDVAAMRSRDWREKLGYTY
GLHGTPTSFVLEARLAEIEGGKYCRVTPSGLAAIAMVNFAFLKSGDDVLLPDNVYGPSKD
LGQWLERDFQITARFYDPMIGEGLAELIRPTTRLVWTEAPGSVSMEVPDIPALCRAAHAK
GVLVAIDNTWSAGIAFKAFEHGVDIVMQAVTKYQSGGSDVLMGAVIVRDQALNEKLELAH
MRLGFGVGMDDVYMVLRSLSSMRLRFEAHDAAARKVAAWLKQRPEIVAVLHPAFEDCPGH
AHWKRDFSGAGGLFSVIFDPRYVEAQTDRFVDSLRLFKIGYSWGGAHSLCVPYRMKGMRR
AWMREGQLVRFNIGLESPEDLIADIEQALARL