Protein Info for HSERO_RS14730 in Herbaspirillum seropedicae SmR1

Annotation: alpha-2-macroglobulin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1700 1800 1900 1968 signal peptide" amino acids 1 to 55 (55 residues), see Phobius details PF11974: bMG3" amino acids 530 to 644 (115 residues), 80.1 bits, see alignment 3.2e-26 PF01835: MG2" amino acids 653 to 739 (87 residues), 60 bits, see alignment (E = 7.4e-20) PF07703: A2M_BRD" amino acids 1044 to 1223 (180 residues), 79.8 bits, see alignment E=7.9e-26 PF00207: A2M" amino acids 1283 to 1370 (88 residues), 40.8 bits, see alignment (E = 4.9e-14) PF17973: bMG10" amino acids 1824 to 1952 (129 residues), 92.3 bits, see alignment 8.8e-30

Best Hits

Predicted SEED Role

"Large extracellular alpha-helical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See D8IZT7 at UniProt or InterPro

Protein Sequence (1968 amino acids)

>HSERO_RS14730 alpha-2-macroglobulin (Herbaspirillum seropedicae SmR1)
MKPTETGARQRPTLLSAIGRISSISRGSRTMHAAALAFALGATMSLLPVKPAQAASATVQ
SFSPQGEVQRIRQVRARFSESMVKFGDPKAASPFDADCAVAGTARWADDRNWVYDFERDL
PPGTRCSFTLRAEAKSVAGNSVGGKTRFQFSTGGPAVSRVQPYSGAQIAEDQAFILFQNG
PATEPSVRQHLYCEAEGINERIPAKAVGEADRKALLQQFAKGVDPASVTIVQCQQRLPNE
AHVKLVWDRGIAAANAPAVVTSQPQVFNFQVRSEFAASLSCQRENANAACSPILPVTLSF
SAPVPRKLAEQVVMNATTGKIKPTLEGDKDEAVRELRFKPPFPEKSDFTISLPSGFKDED
GRTLANAGAFPLKSALADFPPLAKFPAAPFGIIELNADPTLPVTLRRVEAGLQVRGKDGR
AMPGQVADLKVNGDKAVIAWLTRLNKYHEKWGDPKKVDTRSVSLLAKEPGAKKLDLPAQK
DAKEGEWPFEVIGIPLKDPGFYVVELESQKLGASLLGKPQPMYVRTSALVTNLSVHVKLG
RANGAVWVTRLDDAKPVADAEIRVSNCDGAQIWQGKTNASGVAMMPALEDACANRGYSPD
NADKINGLFVSARKTDEKGRQDMAFALTSWNEGIESWRFNLPTDMDKSATVRATTVFDRT
LFRAGETVSMKHVIRTETLQGFGLMRKEDLPTRVRISHLGSGQQYQFPLTWRGNKSAETT
FVLPKQAKLGSYEVVLDQGKVDANASAEPTEQSDDGDYEGGYGRGTYVTGSFRVEEFRLP
LMQGRITPPKGAQVAVKEMPLDLQLNYINGGAAANQAVQVSSLLRSRSLNIAGYDGFSFD
APRSDDDSNADDQKIVADKLAITLDKNGAGRATISKLPALQRPQELLTEMTYSDPNGEVQ
TISNVTPLWPSAVVVGLRTGNWVSVKKKLTLTAVTLNTAGQPQAGVPVEIRGIARKTNSH
RKRMVGGFYAYENDESKQDLGKLCSGKSDQHGMFTCDTELSEAGNVELIASAKDGNGNAA
AARSSVWVTGRGEVWFDGENQDRIDILPEKKNYQPGETANFQVRMPFRSATALVAVEREG
VIDTRVVQLSGQDPTISVPMKAEYGPNVYVSVLAVRGRMREVPWYSFFIWGWKEPINWWH
EFREYQGPGPIVDLSKPAWKFGIAEVNVGDAGHRLQVAVSTDKPTYPIRAIAKVQVQVKL
PNGKPAAGGEFALAAVDEALLELQPNGSWDVLHAMLQRRSYGVETSTAQMQVVGKRHYGK
KATPAGGGGGRAPTRELFDTLLVWKPNVTLDAEGRAQLDVPLNDALTSFRIVAIAENGIS
DFGTGSISIRSTQDVQVISGLPPLVREGDSFNGAVTVRNTTTHDMTIKVAARAQGGTAAS
TLTLPEREVKIAAGQSAEVMWPVQTPEGINQLAWEISAQEQGGQKARDAMKFTQRVVPAV
PVTVQQATLFQLDKNAALDVARPADSLPGRGGLAISLKPSLAGGSDALTRYFVNYPFACL
EQKTSKAIGLRDEAAWQKIVADLPTYLDGDGLAYYFPPSDSGARRGSDTLTAYLLAATNE
AGYAIPQASRDKMLDGLAAFVEGKVMRDFWSPQKDLDVRKLAALEALSRYNRVQPAMLGS
LQINPNVWPTSGLLDWIGILQRVPAIPDRQKKLDEADQILRARLNFQGTRMGFSNEEGDY
WWWLMSSGDANANRLILLELNNPAWREDMPRLIAGAIGRQQRGHWSTTTANVWGSLALEK
FARKFESEPVTGATRATLEQNGASAATQSLAWSGAPNGGKLQLPWPEGNAQGGSVRLAQE
GNGKPWVTLQSLAAVPLKQPFAAGYRITRKVEAIEQKQAGVYTRGDVLRVTLDIDAQAEM
TWVVVSDPVPGGATLLGSGLGRDSAIAQGKQDAPRERGMGWLAYEERSFEAYRAYYEAMP
KGRTSISYTVRLNNAGEFNMPPTRVEAMYAPEMFGEVPNGKLVVKAAQ