Protein Info for HSERO_RS09540 in Herbaspirillum seropedicae SmR1

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 626 PF00563: EAL" amino acids 41 to 267 (227 residues), 162.2 bits, see alignment E=1.4e-51 PF00990: GGDEF" amino acids 441 to 533 (93 residues), 48.3 bits, see alignment E=9.6e-17 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 457 to 531 (75 residues), 43.6 bits, see alignment E=1.3e-15

Best Hits

KEGG orthology group: None (inferred from 100% identity to hse:Hsero_1911)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See D8IS76 at UniProt or InterPro

Protein Sequence (626 amino acids)

>HSERO_RS09540 diguanylate cyclase (Herbaspirillum seropedicae SmR1)
MAPLSNLSFPLGTEVADLIARAAGGTMSGTEDPMLSLLHEIIAQRKLTALFQPIVRMRNG
EILGYEGLIRGPSNTPLHSPLALFKVARAHNMSVQMEYLCRHIVLTRFAQLGLPGNLFLN
VSPGALMQPEAIQGETLRYLDTLGVNPQRIIIELTENEPTYDYAQLRNAAMHYRDMGFQI
AIDDLGEGFSSLRLWSELQPEYVKVDMHFVQGINHDPMKLQFVRSIQEIAEKSGSIVIAE
GIESQAELLTIRDLGIACGQGYHISRPLPEPPVSISDDVTKTLRRDKVPLDAKKYGPGKH
STTVFKLLRETRYVSPEVSNDTVYDMFVNDPQLQALPVVSNGLPIGLINRYSMVERFARL
YGRELYGKKSCAFFMDPNPILTEQSTSLQDLSNLLVHAESHHLSNGFIITDRGQYMGLGT
GHDLLREITQMQIDAARHANPLTQLPGNVPINDHIEYLLQSGVEFCICYCDLDQFKPFND
VYGYRKGDDMIQATGRVLQQACDPELDFIGHIGGDDFLILFQSEDWEKRCRSMLDNFDAE
TRGFYYDEDVERGGYYTEDRQGNRVFHKLVSVSLGAVKIEPSQYSSPHQIASAATRAKKQ
AKKIPGNSLFIERRIPATFSWALKDA