Protein Info for HSERO_RS09395 in Herbaspirillum seropedicae SmR1

Annotation: molybdenum cofactor biosynthesis protein MoaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 428 PF03453: MoeA_N" amino acids 21 to 185 (165 residues), 159.8 bits, see alignment E=6.9e-51 TIGR00177: molybdenum cofactor synthesis domain" amino acids 195 to 334 (140 residues), 111.4 bits, see alignment E=1.8e-36 PF00994: MoCF_biosynth" amino acids 200 to 337 (138 residues), 122.1 bits, see alignment E=2.3e-39 PF03454: MoeA_C" amino acids 352 to 424 (73 residues), 71.3 bits, see alignment E=9.5e-24

Best Hits

Swiss-Prot: 48% identical to MOEA_ECOLI: Molybdopterin molybdenumtransferase (moeA) from Escherichia coli (strain K12)

KEGG orthology group: K03750, molybdopterin biosynthesis protein MoeA (inferred from 100% identity to hse:Hsero_1882)

MetaCyc: 48% identical to molybdopterin molybdotransferase (Escherichia coli K-12 substr. MG1655)
RXN-8348 [EC: 2.10.1.1]

Predicted SEED Role

"Molybdopterin biosynthesis protein MoeA" in subsystem Molybdenum cofactor biosynthesis

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.10.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See D8IRR7 at UniProt or InterPro

Protein Sequence (428 amino acids)

>HSERO_RS09395 molybdenum cofactor biosynthesis protein MoaA (Herbaspirillum seropedicae SmR1)
MTLPSLNDIVSCISGYDPHAMTVERAQAVIREFIHPIEAVEKLPIRSALSRVLAQDIVSR
IDVPAHDNSAMDGYALRGEDLAEGRELRLQIIGEVHAGDRFTGQVGPGQCVRIMTGAPMP
AGCDTVIPQELTVDADQSAVTVPPGRVRAGDNRRLRGEDLALGSVALPRGRILRPSDIGL
LASLGLAEAPVQRRLRVAFFSTGDELRSVGEPLDEGCVYDSNRYTLHGMLTRLGCEVLDM
GVVPDDPAALEAAFRSACEEADAVITSGGVSVGAADYTKQIMASLGEMAFWKIAMRPGRP
LAFGRIRSRGREAYLFGLPGNPVAVTVSFSFFVRDALLRLAGAEAKPLPRLRVKTATAIR
KKAGRTEYQRGILAPDDSGNWSVRLTGMQGSGILRSMSDANCIIELEHDRGDVAAGEEVA
VVLFDGLV