Protein Info for HSERO_RS07715 in Herbaspirillum seropedicae SmR1

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 505 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 198 to 214 (17 residues), see Phobius details amino acids 287 to 309 (23 residues), see Phobius details PF02743: dCache_1" amino acids 40 to 213 (174 residues), 55.2 bits, see alignment E=7.2e-19 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 336 to 503 (168 residues), 170 bits, see alignment E=1.8e-54 PF00990: GGDEF" amino acids 342 to 502 (161 residues), 160.4 bits, see alignment E=3.3e-51

Best Hits

KEGG orthology group: None (inferred from 100% identity to hse:Hsero_1534)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See D8IQ03 at UniProt or InterPro

Protein Sequence (505 amino acids)

>HSERO_RS07715 diguanylate cyclase (Herbaspirillum seropedicae SmR1)
MAQHGKTHTSRTALLFVVVVCVVILLLEAWTAWRAREVALSESTTDASNVALALIQHAEQ
SIKEADIVLETVQEHLDHEDRSASARIRTHDFMIRSVASLPQLAQLTVVDEQGRTVASSQ
QRMVQTGSPVQDDYFQYHQHRRSDRPFIGQPMRSHVTGQRTLTVSRRINHVDGSFAGVIV
AEIDLAYFQRYYEQFNIGPHGVILFGLTGGSLILRRPLLADMTDRSPAMSEALRKHMEQA
RRGSFAMRSERDGVERISCFQQGEAYPIFTVVALAKDDILEDWSRHVWVRGIGVVLLLAV
ICFGGKRLVVLVAGRERAEAQAIAARQELESLYRTLEAQSQKDGLTDVFNRRYFDAALAA
ELARLNRTGESLSLMMIDVDHFKQFNDTYGHAAGDVCLRQVAAAISTVARRQGDIVARYG
GEEFAVILPNCHPGSAQGLAHRVVQAVRGLEIAHERSPMGVVTISVGVASLASGKSLLIE
PRELIDSADGALYRAKEEGRDRAVQ