Protein Info for HSERO_RS07565 in Herbaspirillum seropedicae SmR1

Annotation: acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 594 PF12418: AcylCoA_DH_N" amino acids 2 to 33 (32 residues), 46.9 bits, see alignment (E = 6.9e-16) PF02771: Acyl-CoA_dh_N" amino acids 35 to 156 (122 residues), 47.9 bits, see alignment E=4.8e-16 PF02770: Acyl-CoA_dh_M" amino acids 161 to 270 (110 residues), 47.4 bits, see alignment E=5.2e-16 PF00441: Acyl-CoA_dh_1" amino acids 283 to 448 (166 residues), 92 bits, see alignment E=1.3e-29 PF08028: Acyl-CoA_dh_2" amino acids 304 to 440 (137 residues), 29.8 bits, see alignment E=1.9e-10 PF12806: Acyl-CoA_dh_C" amino acids 465 to 589 (125 residues), 122.9 bits, see alignment E=2.6e-39

Best Hits

Swiss-Prot: 52% identical to DMDC_RUEPO: 3-methylmercaptopropionyl-CoA dehydrogenase (dmdC) from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)

KEGG orthology group: None (inferred from 100% identity to hse:Hsero_1504)

MetaCyc: 52% identical to 3-(methylsulfanyl)propanoyl-CoA dehydrogenase monomer (Ruegeria pomeroyi DSS-3)
RXN-12572 [EC: 1.3.99.41]

Predicted SEED Role

"3-methylmercaptopropionyl-CoA dehydrogenase (DmdC)"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.99.41

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See D8IPX3 at UniProt or InterPro

Protein Sequence (594 amino acids)

>HSERO_RS07565 acyl-CoA dehydrogenase (Herbaspirillum seropedicae SmR1)
MSYTAPVKDMLFVMNELAGLAAVNALPGCEDATPETAEAILEENAKFCSEVVAPLNHSAD
KEPSSWADGKVTTSPGFKEAFRQFGEAGWQGVQHPVEFGGQGLPKLLATPCIEMLNSANL
SFALCPLLTDGTIEALMTAGTQQQKETFIANFISGKWTGTMNLTEPQAGSDLALVRTRAV
PEGDGTYKLFGTKIFITYGEHDMAENIVHLVLARTPNAPEGVKGISLFIVPKFLVNADGS
LGARNDVHCVSIEHKLGIKASPTAVLQFGDHGGAIGTLVGEENRGLEYMFIMMNAARFAV
GIQGLSVSERAYQKAVAYARDRIQSRDLAGSPGPVAIIHQPDVRRMLMSMRAQIEAARAL
SYVAAATSDAAHFSDDEATRKSNQAFYEYLVPIVKGWITEMSIDVTSTGVQVHGGMGFIE
ETGAAQYYRDARILPIYEGTTAIQANDLVGRKTARDGGAVAKGILAQVRKTVSELQGDAQ
LQPIAARLGEAADALEQVVDYVVANVKSDIKAVFAGSVPYLKMAGVVLGGWQMARAAAVS
AAKLKAGEGDGKFYEAKLATARFYADQILPQALAYRTAIVDGGAAVMALAEEQF