Protein Info for HSERO_RS07170 in Herbaspirillum seropedicae SmR1

Annotation: UDP-N-acetylenolpyruvoylglucosamine reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00179: UDP-N-acetylenolpyruvoylglucosamine reductase
  • amino acids 15 to 342 (328 residues), 233.2 bits, E=1.9e-73
• PF01565: FAD_binding_4
  • amino acids 36 to 159 (124 residues), 65.2 bits, E=5.3e-22
• PF02873: MurB_C
  • amino acids 220 to 343 (124 residues), 108.9 bits, E=1.3e-35

Best Hits

Swiss-Prot: 59% identical to MURB_AROAE: UDP-N-acetylenolpyruvoylglucosamine reductase (murB) from Aromatoleum aromaticum (strain EbN1)

KEGG orthology group: K00075, UDP-N-acetylmuramate dehydrogenase [EC: 1.1.1.158] (inferred from 100% identity to hse:Hsero_1426)

Predicted SEED Role

"UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.1.1.158)" in subsystem Peptidoglycan Biosynthesis or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 1.1.1.158)

MetaCyc Pathways

• peptidoglycan biosynthesis I (meso-diaminopimelate containing) (12/12 steps found)
• UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) (8/8 steps found)
• UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) (7/8 steps found)
• UDP-N-acetylmuramoyl-pentapeptide biosynthesis III (meso-diaminopimelate containing) (6/8 steps found)
• peptidoglycan biosynthesis III (mycobacteria) (11/15 steps found)
• peptidoglycan recycling I (10/14 steps found)
• peptidoglycan biosynthesis II (staphylococci) (12/17 steps found)
• peptidoglycan biosynthesis IV (Enterococcus faecium) (12/17 steps found)
• peptidoglycan biosynthesis V (β-lactam resistance) (11/17 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism
• Peptidoglycan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.158

Sequence Analysis Tools

See D8IPC2 at UniProt or InterPro

Protein Sequence (343 amino acids)

>HSERO_RS07170 UDP-N-acetylenolpyruvoylglucosamine reductase (Herbaspirillum seropedicae SmR1)
MTTSSLPLQYAVSLAGLNTFGLQAQAYAYLPVQGADTLHALRQDAALMALPRLVLGGGSN
LLLTQDFPGLVLHMQGRGMTITGEDEDFIYVCAAAGENWHGFVQWTLAQGLGGLENLSLI
PGSVGAAPIQNIGAYGIEVKDRFHSLRAFDLATGEILTLDRDACRFGYRDSVFKHALRDR
AVVLEVSFALPKRWQANANYADVAQALQERGVTEPGPGDIAEAVIAIRTRKLPDPAQIGN
AGSFFKNPIVPARLRDTLLAQYADLVSYRVDEGHYKLAAGWLIDRSGWKGKTVGRAGVYE
KQALVLVNRGGATGAEVARLAKAIQEDVKEKFGVQLEPEPVFI