Protein Info for HSERO_RS01600 in Herbaspirillum seropedicae SmR1
Annotation: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K02510, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [EC: 4.1.2.-] (inferred from 100% identity to hse:Hsero_0323)Predicted SEED Role
"2-dehydro-3-deoxyglucarate aldolase (EC 4.1.2.20)" in subsystem D-galactarate, D-glucarate and D-glycerate catabolism (EC 4.1.2.20)
MetaCyc Pathways
- superpathway of D-glucarate and D-galactarate degradation (5/5 steps found)
- D-glucarate degradation I (4/4 steps found)
- D-galactarate degradation I (4/4 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (16/31 steps found)
KEGG Metabolic Maps
- Ascorbate and aldarate metabolism
- Fructose and mannose metabolism
- Lysine degradation
- Naphthalene and anthracene degradation
- Pentose phosphate pathway
- Phenylalanine, tyrosine and tryptophan biosynthesis
- Tyrosine metabolism
- alpha-Linolenic acid metabolism
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.1.2.- or 4.1.2.20
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See D8IW51 at UniProt or InterPro
Protein Sequence (250 amino acids)
>HSERO_RS01600 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase (Herbaspirillum seropedicae SmR1) MRENRLRTLFAQQQLALSGWVSMGNALLAEVIAHSGYDAVTVDLQHGPFSIDAALPMLQA ISSTPAVPLVRCSENSLGEINKLLDAGAYGVICPLINTAADAERFVRACHYSPRGGRSYG PARGFLYGGADYFTHANATLLTLAMIETREGYANAEAILQTPDLDGIFIGPSDLAIELGL APDAYDDVRLNEAIDHLLALARKLGKYVGIFAGTMEMAQRMKGIGMDLVVPGTDIQQIKA EGARRVSALR