Protein Info for HMPREF1078_RS19150 in Parabacteroides merdae CL09T00C40

Annotation: 4-phosphoerythronate dehydrogenase PdxB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 370 PF00389: 2-Hacid_dh" amino acids 21 to 280 (260 residues), 70.7 bits, see alignment E=1.5e-23 PF02826: 2-Hacid_dh_C" amino acids 110 to 256 (147 residues), 125.4 bits, see alignment E=2.6e-40

Best Hits

Swiss-Prot: 54% identical to PDXB_PORGI: Erythronate-4-phosphate dehydrogenase (pdxB) from Porphyromonas gingivalis (strain ATCC BAA-308 / W83)

KEGG orthology group: K03473, erythronate-4-phosphate dehydrogenase [EC: 1.1.1.290] (inferred from 73% identity to pdi:BDI_2825)

Predicted SEED Role

"Erythronate-4-phosphate dehydrogenase (EC 1.1.1.290)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 1.1.1.290)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.290

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (370 amino acids)

>HMPREF1078_RS19150 4-phosphoerythronate dehydrogenase PdxB (Parabacteroides merdae CL09T00C40)
MKIVADNTVPFLKGIAEPIAEVKYLTSKEFTPENVQDADILIVRSIDKCTRELLEGSRVK
LITSATIGFDHIDTRYCDKAGITWKNSPGCNAVSVAQYVLSGLVTIALRKGEPLQGKTIG
IVGVGHVGKEVEKLCSAYGMNVLRNDPPRAEKEGKDGFVSLETIAEQADIVTFHTPLTKE
GRFATRHLAGEDFFRKLQRKPWFVNASRGAVHDTDALLHARKEGKISELILDCWENEPDI
NRELLELATIATPHIAGFSADGKANGTRMCLKNIEKFFQVKIEKISEVIPPAPETPVIDL
NRFDRNRIEQAILTSFNPLAIDRALRENPDRFEWFRTNYHHPREYGAYTIVHATPEETGQ
LRRLGFGIQQ