Protein Info for HMPREF1078_RS17695 in Parabacteroides merdae CL09T00C40

Annotation: adenosylcobinamide-phosphate synthase CbiB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03186: CobD_Cbib
  • amino acids 18 to 296 (279 residues), 333.3 bits, E=6e-104
• TIGR00380: cobalamin biosynthesis protein CobD
  • amino acids 21 to 271 (251 residues), 223.3 bits, E=2.2e-70

Best Hits

KEGG orthology group: K02227, adenosylcobinamide-phosphate synthase CobD [EC: 6.3.1.10] (inferred from 76% identity to pdi:BDI_3959)

Predicted SEED Role

"Adenosylcobinamide-phosphate synthase (EC 6.3.1.10)" (EC 6.3.1.10)

MetaCyc Pathways

• adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide (6/6 steps found)
• superpathway of adenosylcobalamin salvage from cobinamide II (8/9 steps found)
• adenosylcobinamide-GDP salvage from cobinamide II (5/6 steps found)
• adenosylcobalamin biosynthesis II (aerobic) (20/33 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (22/36 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.1.10

Protein Sequence (317 amino acids)

>HMPREF1078_RS17695 adenosylcobinamide-phosphate synthase CbiB (Parabacteroides merdae CL09T00C40)
MYYWFHQSFYMAKAFPFIGGWLADRLLGDPEGWPHPVVGFGKVISLGEKTLNKGNDRAVK
GGVMALILVAGTYLLCERILALAGYFHPIVASILSGIGVFYCLAGKTLVKEVKAVFEAVD
RSTEEGRKQVGRIVGRDTSRLSPQEIRAAALETLAENLSDGVIAPMFWFALLGLPGMMTY
KMVNTLDSMIGYKNERYLEFGQIAARLDDLANYIPARLTAWLMLAVSGNLNKTDFVKRFG
PAHASPNSGYPESALAAILNCRFGGTHDYFGKPVEKPYIGTNERTFTTEDMLIAIKTNSN
AELAMGLIVCLISIIIH