Protein Info for HMPREF1078_RS17240 in Parabacteroides merdae CL09T00C40

Annotation: GTPase Era

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 296 TIGR00231: small GTP-binding protein domain" amino acids 8 to 161 (154 residues), 80.4 bits, see alignment E=1.3e-26 TIGR00436: GTP-binding protein Era" amino acids 8 to 276 (269 residues), 270.6 bits, see alignment E=1.4e-84 PF01926: MMR_HSR1" amino acids 10 to 123 (114 residues), 87.9 bits, see alignment E=1.8e-28 PF02421: FeoB_N" amino acids 10 to 165 (156 residues), 49.4 bits, see alignment E=1.3e-16 PF10662: PduV-EutP" amino acids 12 to 167 (156 residues), 26.7 bits, see alignment E=1.5e-09 PF00009: GTP_EFTU" amino acids 21 to 171 (151 residues), 38 bits, see alignment E=4.6e-13 PF07650: KH_2" amino acids 206 to 282 (77 residues), 72.2 bits, see alignment E=8.5e-24

Best Hits

Swiss-Prot: 56% identical to ERA_AMOA5: GTPase Era (era) from Amoebophilus asiaticus (strain 5a2)

KEGG orthology group: K03595, GTP-binding protein Era (inferred from 93% identity to pdi:BDI_2435)

Predicted SEED Role

"GTP-binding protein Era" in subsystem Bacterial Cell Division or Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (296 amino acids)

>HMPREF1078_RS17240 GTPase Era (Parabacteroides merdae CL09T00C40)
MENKHKSGFVNIVGNPNVGKSTLMNRLVGERISIITSKAQTTRHRIIGIVNTADMQIVYS
DTPGVLHPNYKLQESMLNFSQSALGDADVLLYVTDVVEKIDKNEEFLQKVQKVECPVLLL
INKIDTTTQPELEKLVAEWKELLPKAEIIPISALSNFNIDYVKRRVEDLMPESPPYFEKD
ALTDKPARFFVTEIIREKILLYYQKEIPYAVEVVVELFKEEAELIHIKALIIVERDSQKG
IIIGYRGQALKKVGAMARKDIERFFDKKVFLEMFVKVEKDWRNRDNMLKNFGYQLD