Protein Info for HMPREF1078_RS17065 in Parabacteroides merdae CL09T00C40

Annotation: CPBP family intramembrane metalloprotease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 301 transmembrane" amino acids 12 to 43 (32 residues), see Phobius details amino acids 56 to 77 (22 residues), see Phobius details amino acids 96 to 117 (22 residues), see Phobius details amino acids 149 to 171 (23 residues), see Phobius details amino acids 191 to 213 (23 residues), see Phobius details amino acids 225 to 227 (3 residues), see Phobius details amino acids 232 to 250 (19 residues), see Phobius details amino acids 270 to 288 (19 residues), see Phobius details PF02517: Rce1-like" amino acids 157 to 245 (89 residues), 65.3 bits, see alignment E=2.5e-22

Best Hits

KEGG orthology group: K07052, (no description) (inferred from 62% identity to pdi:BDI_2398)

Predicted SEED Role

"abortive infection protein family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (301 amino acids)

>HMPREF1078_RS17065 CPBP family intramembrane metalloprotease (Parabacteroides merdae CL09T00C40)
MFLKGIYAGKPAIFQLTVLLLLILAGAVFSSLIVMGFFYMIYGLHADITQYSDMMRLLQL
ISALGTFLFPALALAWLCSYNPKEYLSIGKMPKGHILLLTFLSIFLITPSISLTGILNKQ
MELPSFMEPIENWMRLQEETAEQLTLKLLAGRGIITLFFNLIVIAVAAGITEEFLFRGAL
QRIIGKWTYNHHIIIWSAAIIFSTFHMQFFGFLPRMLLGAYFGYLLYWTRNIWIPVFAHF
VNNAIAVISMSDAKLKDNEFITGDISTQNLLPYTIVAIVALFFFVRCCRKLKIIRSSNLN
S