Protein Info for HMPREF1078_RS17050 in Parabacteroides merdae CL09T00C40

Annotation: ATP-dependent Clp endopeptidase proteolytic subunit ClpP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 221 transmembrane" amino acids 115 to 134 (20 residues), see Phobius details PF00574: CLP_protease" amino acids 44 to 218 (175 residues), 270.3 bits, see alignment E=4.4e-85

Best Hits

Swiss-Prot: 83% identical to CLPP_PORGI: ATP-dependent Clp protease proteolytic subunit (clpP) from Porphyromonas gingivalis (strain ATCC BAA-308 / W83)

KEGG orthology group: K01358, ATP-dependent Clp protease, protease subunit [EC: 3.4.21.92] (inferred from 90% identity to pdi:BDI_2396)

MetaCyc: 60% identical to ClpP2 (Synechococcus elongatus PCC 7942 = FACHB-805)

Predicted SEED Role

"ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent or cAMP signaling in bacteria (EC 3.4.21.92)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.92

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (221 amino acids)

>HMPREF1078_RS17050 ATP-dependent Clp endopeptidase proteolytic subunit ClpP (Parabacteroides merdae CL09T00C40)
MEDFRKYATKHLGMNSNALDSYMNITSSYISPTIIEERQLNVAQMDVFSRLMMDRIIFLG
TQVDDYTANVIQAQLLYLDSSDPGKDISIYINSPGGSVYAGYGIYDTMQFISSDVSTICT
GMAASFAAVLLVAGTKGKRMALPHSRVMIHQPLGGAQGQASDIEITAREILKVKKELYTI
ISTHSGQPYEKVEHDSDRDYWMTAEEALAYGMIDKVLVRNK