Protein Info for HMPREF1078_RS16790 in Parabacteroides merdae CL09T00C40

Annotation: S9 family peptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 724 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF00930: DPPIV_N" amino acids 99 to 441 (343 residues), 343.2 bits, see alignment E=3.5e-106 PF07676: PD40" amino acids 134 to 160 (27 residues), 20.1 bits, see alignment (E = 1.2e-07) PF02129: Peptidase_S15" amino acids 488 to 639 (152 residues), 32 bits, see alignment E=2.7e-11 PF00326: Peptidase_S9" amino acids 525 to 723 (199 residues), 189.4 bits, see alignment E=1.5e-59 PF01738: DLH" amino acids 568 to 702 (135 residues), 21.7 bits, see alignment E=3.3e-08

Best Hits

KEGG orthology group: K01278, dipeptidyl-peptidase 4 [EC: 3.4.14.5] (inferred from 84% identity to pdi:BDI_2193)

Predicted SEED Role

"Dipeptidyl peptidase IV"

Isozymes

Compare fitness of predicted isozymes for: 3.4.14.5

Use Curated BLAST to search for 3.4.14.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (724 amino acids)

>HMPREF1078_RS16790 S9 family peptidase (Parabacteroides merdae CL09T00C40)
MKRLGFGALLSFLLVGSLAAQNGSKRVDLKEITDGQFRQVTNIGEMRSMPDGEHYTAMND
ARNMIIKYSYRTGNPVDTLFNTEKARECTFDKFDGYTISSTGHHILVWRDTEPIYRRSFK
ANVYDYDVRRNYVKPISDSKGKQMIPTFSPDGRMVAYVSDNNIWIRKFDYDTEVQVTKDG
EMNKILNGITDWVYEEEFAVTNLMAWSPNSEQLAFVRFDESEVPEYSMQMFGEGLYPGYY
NYKYPKAGEKNSKVTLHSYDVTTKDTKELKVPVEADSYIPRIVFTNNDDQLAVMTLNRHQ
NVFNMYYANPKSGVFRLILRDENKAYVDSEWLNSIHFYANSFSYVNEQDGYAHIYLYSPT
GVMQRQVTKGNWDVTAFLGYDEATKTVYYESAEESPIRRAIYKIDAKGVKTKLSTQEGTN
NATFSDNFAYYVNQYSNANTPVKITVNETKSNKVLRVLQDNARLVDKLAGYSYAEKEFIK
VRTASDYELNAWIVKPVDFDESKKYPVLMFQYSGPNSQQVLDKYSFDWEQYLAANGIITV
CVDGRGTGARGEAFRKCTYLRMGELESKDQVEAAQALGKLPFVDKNRMAIWGWSFGGYNT
LMAMSVGNGTFKAGIAVAPPTDWKYYDSVYTERFMRTPKENFEGYAATSPIRLAKDLQGK
LLLIHGTADDNVHFQQTMDYAESLVQAGKQFEMQVYKDRNHSIYGGNTRYHLYTRMSNFL
FDNL