Protein Info for HMPREF1078_RS16405 in Parabacteroides merdae CL09T00C40

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 451 transmembrane" amino acids 18 to 36 (19 residues), see Phobius details amino acids 60 to 84 (25 residues), see Phobius details amino acids 95 to 118 (24 residues), see Phobius details amino acids 138 to 160 (23 residues), see Phobius details amino acids 171 to 191 (21 residues), see Phobius details amino acids 200 to 219 (20 residues), see Phobius details amino acids 245 to 266 (22 residues), see Phobius details amino acids 286 to 308 (23 residues), see Phobius details amino acids 320 to 340 (21 residues), see Phobius details amino acids 360 to 379 (20 residues), see Phobius details amino acids 388 to 409 (22 residues), see Phobius details amino acids 417 to 437 (21 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 25 to 419 (395 residues), 263.6 bits, see alignment E=1.4e-82 PF01554: MatE" amino acids 25 to 185 (161 residues), 113.8 bits, see alignment E=6.8e-37 amino acids 247 to 407 (161 residues), 104.8 bits, see alignment E=4e-34 PF14667: Polysacc_synt_C" amino acids 140 to 225 (86 residues), 40.2 bits, see alignment E=3.7e-14

Best Hits

KEGG orthology group: None (inferred from 81% identity to pdi:BDI_0356)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (451 amino acids)

>HMPREF1078_RS16405 MATE family efflux transporter (Parabacteroides merdae CL09T00C40)
MDKRKGNTDLTEGKVWKVIVRFALPLLVGNLLQQFYNITDSIIVGQFLGKEALAAVSASF
FIYYFIISLVIGVGSGTTVVISQLFGAKQYQKVQLAFSSFFIFMLVGGIILSIAGIIFAE
PVFRLTNTPEEVIPQAVAYFRIYIGGTFLFVTFNSIISILRGVGESVRPMLFILITTVLN
IAFDLLFILVFKWGIEGAARATVVSQGIGMCIALAYVNNTHPLLSIKKQDMLFDWKLFKE
SLKIGLPTSVQQCAIALGLIALLGIVNSFGTNTLTAYGAAGKIDTIITQAILTLSGALAA
FCGQNIGAGRLDRVKKGVQFTMYTNIALGLLTFAAVYLFGNEMMRIFTKDIDVVAIGKEY
LLIIGGFFIVHGALNVYNGALRGAGDTLFPMITSLVCLWLIRIPLAYYLSSWLGRNGIWW
AIGISITIGLIVTFVYYKIGFWKRRRRIYEL