Protein Info for HMPREF1078_RS15780 in Parabacteroides merdae CL09T00C40

Annotation: nucleobase:cation symporter-2 family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 456 transmembrane" amino acids 34 to 59 (26 residues), see Phobius details amino acids 66 to 84 (19 residues), see Phobius details amino acids 103 to 133 (31 residues), see Phobius details amino acids 145 to 167 (23 residues), see Phobius details amino acids 183 to 202 (20 residues), see Phobius details amino acids 213 to 236 (24 residues), see Phobius details amino acids 256 to 276 (21 residues), see Phobius details amino acids 341 to 363 (23 residues), see Phobius details amino acids 369 to 389 (21 residues), see Phobius details amino acids 398 to 416 (19 residues), see Phobius details amino acids 428 to 448 (21 residues), see Phobius details TIGR00801: uracil-xanthine permease" amino acids 27 to 446 (420 residues), 375.5 bits, see alignment E=3.5e-116 PF00860: Xan_ur_permease" amino acids 32 to 416 (385 residues), 300.2 bits, see alignment E=9.9e-94 TIGR03173: xanthine permease" amino acids 37 to 448 (412 residues), 448.6 bits, see alignment E=1.8e-138

Best Hits

KEGG orthology group: K03458, nucleobase:cation symporter-2, NCS2 family (inferred from 88% identity to pdi:BDI_1503)

Predicted SEED Role

"Xanthine permease" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (456 amino acids)

>HMPREF1078_RS15780 nucleobase:cation symporter-2 family protein (Parabacteroides merdae CL09T00C40)
MKLNLEEQEETIEPVEKTDLIYGIDDRPPFKEALFAALQHLLAIFVAIITPPLIIAGALK
LDLETTGFLVSMALFASGVSTFIQCRRIGPVGAKLLCIQGTSFSFIGPIITAGLAGGLPL
IFGACIAAAPIEMVISRTFKYMRSIITPLVSGIVVLLIGLSLIKVGVVSCGGGYGAMDNG
TFGSIRNIGVAATVLLSVLFFNRCKNKYLRMSSIVLGLCIGYALAYFLGMVDMAAASSQS
LMGFNIPMPFKYGLDLNFSAFVAIGLVYLITAIEATGDVTANSMISGKSIEGEDYLKRVS
GGVLADGVNSFIVGIFNSFPNSIFAQNNGIIQLTGVASRYVGYYIAGMLVLLGLFPVVGV
VFSLMPDPVLGGATLLMFGTVAAAGIRIIASQEINRKATLVLAVSLSLGLGVELMPDILN
TAPEAVKGIFSSGITTGGLAAIIANVLIRVKEDKTE