Protein Info for HMPREF1078_RS15750 in Parabacteroides merdae CL09T00C40

Annotation: cation:proton antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 755 transmembrane" amino acids 6 to 25 (20 residues), see Phobius details amino acids 32 to 53 (22 residues), see Phobius details amino acids 59 to 78 (20 residues), see Phobius details amino acids 88 to 108 (21 residues), see Phobius details amino acids 119 to 138 (20 residues), see Phobius details amino acids 150 to 175 (26 residues), see Phobius details amino acids 188 to 209 (22 residues), see Phobius details amino acids 221 to 238 (18 residues), see Phobius details amino acids 244 to 262 (19 residues), see Phobius details amino acids 274 to 293 (20 residues), see Phobius details amino acids 299 to 320 (22 residues), see Phobius details amino acids 332 to 352 (21 residues), see Phobius details amino acids 358 to 378 (21 residues), see Phobius details amino acids 422 to 446 (25 residues), see Phobius details amino acids 456 to 478 (23 residues), see Phobius details amino acids 499 to 519 (21 residues), see Phobius details amino acids 526 to 545 (20 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 13 to 377 (365 residues), 206.6 bits, see alignment E=5.8e-65 PF02080: TrkA_C" amino acids 592 to 661 (70 residues), 52.9 bits, see alignment E=2.8e-18 amino acids 682 to 744 (63 residues), 55.4 bits, see alignment E=4.4e-19

Best Hits

KEGG orthology group: K03455, monovalent cation:H+ antiporter-2, CPA2 family (inferred from 86% identity to pdi:BDI_0523)

Predicted SEED Role

"POTASSIUM/PROTON ANTIPORTER ROSB" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (755 amino acids)

>HMPREF1078_RS15750 cation:proton antiporter (Parabacteroides merdae CL09T00C40)
MSQIPSLISDLAVILISAGLVTLLFKWLKQPVVLGYIVAGILAGPSITQIPTVTNIESIR
IWADIGVIFLLFALGLDFSFKKLMKVGGTAVIGAITIVIGMMTLGYTTGLSLGWGHMNSL
FLGGMLSMSSTTIIFKAFDDMGLRNQRFAGVVFGILVVEDLFAVLLMVLLSTLAVSKHVE
GMELLNSVIKLGVFLLFCFVIGIYLIPSFLKKARTFLNDETLLIVSLGLCLGMVIIATKA
GFSSALGAFVMGSILAETIDAEHIEHIIKPVKDLFGAIFFVSVGMLIDPALLWEYKIPIL
ILTLVVMTGQILFASFGVLLSGQPVKIAIQSGFSLAQIGEFAFIIASLGLSLGVTDNFLY
PIVVAVSVVTTFFTPYMIRMAEPACRVADRIIPKSWMKFLERYSSGSNTIHQKSAWNKLL
KALIRIVGTYTAVTLVLIFIWLQFIAPFIMKELPGIRGAGISLVLILLLIAPMLRAIMMK
KNHSAEFQQLWLDSKYNRGPLVSLVILRIILCIGLVMLPVARLLNATVGIVLAIAATVIV
IVILSKRLKRQSILMERHFFSNLSARELENERKAPINQRFANHLLERDLHLADFEVKQNS
PSMGKTLKELNFRQKCNVNIVTIIRGEQRINIPGGEERLYPFDKLVVVGADVDLEHFRQY
LVERYKKAQTDKEQTTHEVNMEQFTIAEGSHLIGRTILESGIRDRSACLVIGIERGSSSI
KNPSPSTVFEEGDIVWIVGEHEKVVQLSEGKTVNN