Protein Info for HMPREF1078_RS15745 in Parabacteroides merdae CL09T00C40

Annotation: 3-deoxy-manno-octulosonate cytidylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 261 TIGR00466: 3-deoxy-D-manno-octulosonate cytidylyltransferase" amino acids 1 to 241 (241 residues), 229.5 bits, see alignment E=2e-72 PF02348: CTP_transf_3" amino acids 4 to 222 (219 residues), 185.6 bits, see alignment E=1.1e-58 PF12804: NTP_transf_3" amino acids 13 to 152 (140 residues), 42.2 bits, see alignment E=9.6e-15

Best Hits

Swiss-Prot: 85% identical to KDSB_PARD8: 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB) from Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)

KEGG orthology group: K00979, 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC: 2.7.7.38] (inferred from 85% identity to pdi:BDI_0522)

Predicted SEED Role

"3-deoxy-manno-octulosonate cytidylyltransferase (EC 2.7.7.38)" in subsystem KDO2-Lipid A biosynthesis (EC 2.7.7.38)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.38

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (261 amino acids)

>HMPREF1078_RS15745 3-deoxy-manno-octulosonate cytidylyltransferase (Parabacteroides merdae CL09T00C40)
MKFIGIIPARYASTRFPGKPLADLAGKPMIQRVYEQVQNVLDSVCVATDDNRIEAAVQAF
GGNVIMTSDQHKSGTDRCYEAYCKIGDGYDVVVNIQGDEPFIQPEQIEILKACFIDDSIQ
IATLVKPFRPDDDFETTLFNANSPKVVLNKKNEAMYFSRSIIPYMRGRKYTEWLPNHTYY
KHIGLYAYRADTLKEITHLPQSPLELAESLEQLRWLENGYKIKVGITQQETIGIDTPEDM
EKALAFLKNREYQPTNESASA