Protein Info for HMPREF1078_RS15740 in Parabacteroides merdae CL09T00C40

Annotation: membrane protein insertase YidC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 638 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 355 to 374 (20 residues), see Phobius details amino acids 382 to 403 (22 residues), see Phobius details amino acids 451 to 473 (23 residues), see Phobius details amino acids 507 to 526 (20 residues), see Phobius details amino acids 546 to 563 (18 residues), see Phobius details amino acids 569 to 588 (20 residues), see Phobius details TIGR03593: membrane protein insertase, YidC/Oxa1 family, N-terminal domain" amino acids 2 to 361 (360 residues), 68.2 bits, see alignment E=1e-22 PF14849: YidC_periplas" amino acids 97 to 369 (273 residues), 101.6 bits, see alignment E=7.9e-33 TIGR03592: membrane protein insertase, YidC/Oxa1 family" amino acids 382 to 585 (204 residues), 179.8 bits, see alignment E=6.2e-57 PF02096: 60KD_IMP" amino acids 383 to 585 (203 residues), 172.4 bits, see alignment E=8.2e-55

Best Hits

Swiss-Prot: 78% identical to YIDC_PARD8: Membrane protein insertase YidC (yidC) from Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)

KEGG orthology group: K03217, preprotein translocase subunit YidC (inferred from 78% identity to pdi:BDI_0520)

Predicted SEED Role

"Inner membrane protein translocase component YidC, long form"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (638 amino acids)

>HMPREF1078_RS15740 membrane protein insertase YidC (Parabacteroides merdae CL09T00C40)
MDKNTIIGFLLIGVVLIVFTWLNQPTPEQIEAQRRMQDSIARIEYAKQLEQQKELNREAK
ADDELAGLPDSVRLARLQNTFGVFADAMIGEEGSTVLENELIEVRLANKGGRIGYVRLKK
YDNYKGEPLVLFDEKDSKFDFTLVTADNRVVNTGDLYFTPVKGNDRNSITMRLNTGEGSH
LDFMYTLKPDDYMLQFSIKGTGLNGVLSPGTTALDLLWQQKIIQQEKGRKFEDRYATVYY
KFMADDVEYLSETKNDSKQLSNRLKWVAYKDMYFSSILIAGNEGFESTTIDSKMLPEDGS
FLKEYKTTTSVPFDLKGNEATDMRFYFGPNQFSLLKSYDDDVEKADQLDLEKIVPLGWGI
FRWVNQYFVIPLFNFLGQFIHSYGLLIFLLTVIVKLILFPLTYKSYMSSAKMRVLRPQVE
ELNAKYPGQDKAVERQRAIMELYSRAGASPMAGCVPMLLQMPILVALFMFFPSAIELRHQ
SFLWAHDLSTYDAIVSWNTYIPIITPYFGNHISLFCLLMTVTNIIYTKFNMDQTNTGQQQ
MPGMKAMMYMMPLMMLVFFNQYASGLTYYYFISTLITILQTVIFRYTINEDKLLAKLEEN
KKKPMKKSGFMKRLEEAQKAQQAQLERQKQQRENNRRR