Protein Info for HMPREF1078_RS15565 in Parabacteroides merdae CL09T00C40
Annotation: N-acetylglucosamine-6-phosphate deacetylase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01443, N-acetylglucosamine-6-phosphate deacetylase [EC: 3.5.1.25] (inferred from 95% identity to pdi:BDI_0236)Predicted SEED Role
"N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)" in subsystem Chitin and N-acetylglucosamine utilization or Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 3.5.1.25)
MetaCyc Pathways
- N-acetylglucosamine degradation II (3/3 steps found)
- N-acetylglucosamine degradation I (2/2 steps found)
- superpathway of N-acetylneuraminate degradation (16/22 steps found)
- D-galactosamine and N-acetyl-D-galactosamine degradation (2/4 steps found)
- superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation (3/6 steps found)
- N-acetyl-D-galactosamine degradation (2/5 steps found)
- chitin derivatives degradation (3/8 steps found)
- peptidoglycan recycling I (7/14 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 3.5.1.25
Use Curated BLAST to search for 3.5.1.25
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (388 amino acids)
>HMPREF1078_RS15565 N-acetylglucosamine-6-phosphate deacetylase (Parabacteroides merdae CL09T00C40) MLTQIINGKILTPQGWLKDGSVLISDNKILEVTNCDLAVVGATLIDAKGMYIVPGGVEIH VHGGGGRDFMEGTEEAFRAAVAAHMQHGTTSIFPTLSSSTIPMIREAAATTEKLMAEKDS PVLGLHLEGHYFNMKMAGGQLPENIKNPDPEEYIPLLDETHCIKRWDAAPELPGAMQFGK YVTSKGVLASVGHTQAEYEDIQTAYEAGYTHATHFYNAMPGFHKRREYKYEGTVESIYLI DDMTVEVVADGIHVPPTILRLVYKIKGVERTCLITDALACAASDSQTAFDPRVIIEDGVC KLADRSALAGSIATMDRLIRTMVQKAEIPLEDAVRMASETPARIMGVYDRKGSLQRGKDA DIQILDKDLNVRAVWAMGKLVEGTNKLF